No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
Objectives: the aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) ‘pain sensitivity’ haplotypes and chronic widespread pain (CWP) in two distinct cohorts.
Methods: cases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIFUND study had three time points and cases were classified as subjects with CWP at two or three time points and controls as those free of pain at all three time points. Four single nucleotide polymorphisms (SNP): rs6269, rs4633, rs4818 and rs4680 (V158M) were genotyped using Sequenom technology. Allele and genotype frequencies were compared and haplotype analysis was conducted using PLINK software.
Results: no differences in allele or genotype frequencies for any of the four SNP were observed between cases and controls for either cohort. Haplotype analysis also showed no difference in the frequency of haplotypes between cases and controls.
Conclusions: there was no evidence of association between the COMT ‘pain sensitivity’ haplotypes and CWP in two population-based cohorts.
2009-2012
Nicholl, Barbara I.
3922cf66-6e36-44d2-9d8b-1736123e0e53
Holliday, Kate L.
58c01428-143a-4fc8-bd97-eb513573a697
Macfarlane, Gary J.
e17bbdb7-9d82-42ac-8a0a-09bf10885e3c
Thomson, Wendy
1e15e3f0-5128-496d-a2bd-da122d42ddfa
Davies, Kelly A.
caee283e-3742-4cf7-9065-8f02d4ca0f59
O'Neill, Terence W.
d7396fa9-14be-42e9-80d9-4a857f77309e
Bartfai, György
fe863ca6-a92f-49a7-b381-0780b750a47c
Boonen, Steven
19c70ece-493f-4b7c-9bf9-5e4a4a887ba4
Casanueva, Felipe
a78fbfbf-9f03-4f71-ad84-607a5c86f5c4
Finn, Joseph D.
b4c192dd-0d77-42d0-a7a3-f54e17d87ee7
Forti, Gianni
773d94d6-5386-49ef-800d-450b304fa340
Giwercman, Aleksander
4efe31ca-8f8b-4447-a6d9-8998f4cf5da9
Huhtaniemi, Ilpo T.
44b7325c-b07b-43c2-8637-a815cb437f0b
Kula, Krzysztof
c3ed513e-a509-4a1f-96f2-5f2bf9765a40
Punab, Margus
82034cd3-6df3-4feb-b6b3-791c0f887a60
Silman, Alan J.
1ab1fc13-51f5-44c8-92f1-0bb32a5c5754
Vanderschueren, Dirk
de49cace-a8d0-4ca0-bc39-274b55506a68
Wu, Frederick C.W.
996721f2-a975-4136-aca9-9f4a88b5b881
Petrone, L.
b7f3d32f-03df-414c-8e3d-44929f403977
McBeth, John
98012716-66ba-480b-9e43-ac53b51dce61
Cilotti, A.
efc9a582-68f3-412d-b7b2-14ac7db2e918
Borghs, H.
51712192-32cb-4435-9e45-8d7d76458c5f
Slowikowska-Hilczer, J.
1e2fb665-1a57-4edf-9758-390d1f8d767c
Walczak-Jedrzejowska, R.
c8ade629-5187-4d41-b143-851f40205051
Steer, P.
d78e3dc1-8d02-42b4-8a9a-6a6e3a3a13a2
Tajar, A.
fb5a5ad6-ddca-4ff3-8649-b00e208f9254
Lee, D.
88f534dd-a24f-403a-a72e-fab24c2e2b8d
Pye, S.
a63594ba-fdba-4e0c-a193-0178ad8ef06c
Ocampo, M.
f9a56808-e5aa-43b2-b258-9fb897f1467f
Lage, M.
8de24f57-4c52-4fe6-b376-cc64cd7c69b4
Földesi, I.
bc5b2d39-a855-49b8-a8b3-82420a321a60
Fejes, I.
362624f7-c589-4343-aece-1e33badc0a0c
Korrovitz, P.
1bfc0c83-bdbc-4255-9c69-b94a31678e59
Jiang, M.
64b09206-9d05-4fa3-9749-81ea8bb5347c
the European Male Ageing Study Group
22 June 2010
Nicholl, Barbara I.
3922cf66-6e36-44d2-9d8b-1736123e0e53
Holliday, Kate L.
58c01428-143a-4fc8-bd97-eb513573a697
Macfarlane, Gary J.
e17bbdb7-9d82-42ac-8a0a-09bf10885e3c
Thomson, Wendy
1e15e3f0-5128-496d-a2bd-da122d42ddfa
Davies, Kelly A.
caee283e-3742-4cf7-9065-8f02d4ca0f59
O'Neill, Terence W.
d7396fa9-14be-42e9-80d9-4a857f77309e
Bartfai, György
fe863ca6-a92f-49a7-b381-0780b750a47c
Boonen, Steven
19c70ece-493f-4b7c-9bf9-5e4a4a887ba4
Casanueva, Felipe
a78fbfbf-9f03-4f71-ad84-607a5c86f5c4
Finn, Joseph D.
b4c192dd-0d77-42d0-a7a3-f54e17d87ee7
Forti, Gianni
773d94d6-5386-49ef-800d-450b304fa340
Giwercman, Aleksander
4efe31ca-8f8b-4447-a6d9-8998f4cf5da9
Huhtaniemi, Ilpo T.
44b7325c-b07b-43c2-8637-a815cb437f0b
Kula, Krzysztof
c3ed513e-a509-4a1f-96f2-5f2bf9765a40
Punab, Margus
82034cd3-6df3-4feb-b6b3-791c0f887a60
Silman, Alan J.
1ab1fc13-51f5-44c8-92f1-0bb32a5c5754
Vanderschueren, Dirk
de49cace-a8d0-4ca0-bc39-274b55506a68
Wu, Frederick C.W.
996721f2-a975-4136-aca9-9f4a88b5b881
Petrone, L.
b7f3d32f-03df-414c-8e3d-44929f403977
McBeth, John
98012716-66ba-480b-9e43-ac53b51dce61
Cilotti, A.
efc9a582-68f3-412d-b7b2-14ac7db2e918
Borghs, H.
51712192-32cb-4435-9e45-8d7d76458c5f
Slowikowska-Hilczer, J.
1e2fb665-1a57-4edf-9758-390d1f8d767c
Walczak-Jedrzejowska, R.
c8ade629-5187-4d41-b143-851f40205051
Steer, P.
d78e3dc1-8d02-42b4-8a9a-6a6e3a3a13a2
Tajar, A.
fb5a5ad6-ddca-4ff3-8649-b00e208f9254
Lee, D.
88f534dd-a24f-403a-a72e-fab24c2e2b8d
Pye, S.
a63594ba-fdba-4e0c-a193-0178ad8ef06c
Ocampo, M.
f9a56808-e5aa-43b2-b258-9fb897f1467f
Lage, M.
8de24f57-4c52-4fe6-b376-cc64cd7c69b4
Földesi, I.
bc5b2d39-a855-49b8-a8b3-82420a321a60
Fejes, I.
362624f7-c589-4343-aece-1e33badc0a0c
Korrovitz, P.
1bfc0c83-bdbc-4255-9c69-b94a31678e59
Jiang, M.
64b09206-9d05-4fa3-9749-81ea8bb5347c