Gastroschisis associated changes in the placental transcriptome
Gastroschisis associated changes in the placental transcriptome
The congenital condition gastroschisis is associated with delayed villous development and placental malperfusion, suggesting placental involvement. This study uses RNA sequencing to compare the placental transcriptome in pregnancies with and without gastroschisis. 180 coding genes were differentially expressed, mapping to multiple gene ontology pathways. Altered placental gene expression may represent fetal signalling to the placenta, and these changes could contribute to the pathogenesis of gastroschisis and associated morbidities, including fetal growth restriction.
Fetal growth restriction, Gastroschisis, Prematurity
38-41
Jongen, Maaike
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Reddin, Ian
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Cave, Sharon
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Cashmore, Lianne
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Pond, Jenny
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Cleal, Jane K.
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Hall, Nigel J.
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Lewis, Rohan M.
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12 June 2024
Jongen, Maaike
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Reddin, Ian
b5f50ec1-83fb-4f15-a41f-f9c544d7ccc0
Cave, Sharon
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Cashmore, Lianne
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Pond, Jenny
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Cleal, Jane K.
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Hall, Nigel J.
6919e8af-3890-42c1-98a7-c110791957cf
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Jongen, Maaike, Reddin, Ian, Cave, Sharon, Cashmore, Lianne, Pond, Jenny, Cleal, Jane K., Hall, Nigel J. and Lewis, Rohan M.
(2024)
Gastroschisis associated changes in the placental transcriptome.
Placenta, 154, .
(doi:10.1016/j.placenta.2024.06.001).
Abstract
The congenital condition gastroschisis is associated with delayed villous development and placental malperfusion, suggesting placental involvement. This study uses RNA sequencing to compare the placental transcriptome in pregnancies with and without gastroschisis. 180 coding genes were differentially expressed, mapping to multiple gene ontology pathways. Altered placental gene expression may represent fetal signalling to the placenta, and these changes could contribute to the pathogenesis of gastroschisis and associated morbidities, including fetal growth restriction.
Text
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Accepted/In Press date: 2 June 2024
e-pub ahead of print date: 4 June 2024
Published date: 12 June 2024
Keywords:
Fetal growth restriction, Gastroschisis, Prematurity
Identifiers
Local EPrints ID: 491655
URI: http://eprints.soton.ac.uk/id/eprint/491655
ISSN: 0143-4004
PURE UUID: 100cb495-449b-433a-a329-5ac9b788e566
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Date deposited: 03 Jul 2024 09:40
Last modified: 15 Aug 2024 02:17
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Contributors
Author:
Maaike Jongen
Author:
Ian Reddin
Author:
Sharon Cave
Author:
Lianne Cashmore
Author:
Jenny Pond
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