Effects of blood pressure on brain tissue pulsation amplitude in a phantom model
Effects of blood pressure on brain tissue pulsation amplitude in a phantom model
Objective: the precise mechanism and determinants of brain tissue pulsations (BTPs) are poorly understood, and the impact of blood pressure (BP) on BTPs is relatively unexplored. This study aimed to explore the relationship between BP parameters (mean arterial pressure [MAP] and pulse pressure [PP]) and BTP amplitude, using a transcranial tissue Doppler prototype.
Methods: a phantom brain model generating arterial-induced BTPs was developed to observe BP changes in the absence of confounding variables and cerebral autoregulation feedback processes. A regression model was developed to investigate the relationship between bulk BTP amplitude and BP. The separate effects of PP and MAP were evaluated and quantified.
Results: the regression model (R2 = 0.978) revealed that bulk BTP amplitude measured from 27 gates significantly increased with PP but not with MAP. Every 1 mm Hg increase in PP resulted in a bulk BTP amplitude increase of 0.29 µm.
Conclusion: increments in BP were significantly associated with increments in bulk BTP amplitude. Further work should aim to confirm the relationship between BP and BTPs in the presence of cerebral autoregulation and explore further physiological factors having an impact on BTP measurements, such as cerebral blood flow volume, tissue distensibility and intracranial pressure.
2134-2139
Nicholls, Jennifer K.
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Turner, Poppy
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Lecchini-Visintini, Andrea
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Ince, Jonathan
55157657-56bb-45ef-b67c-1ff1c23ab4dd
de Vries, Georgina
b5d1861f-c0e5-4506-b508-e69e54dc7cbb
Cappellugola, Laurie
a864c3ad-1640-409f-84c5-95b1a31963b9
Oura, Mitsuhiro
8118dd55-12b5-4161-bc66-c3cc54630f10
Ebirim, Kelechi U.
244d469b-dcb5-44c2-9597-371035b5167d
Pallett, Edward
60654e18-a8cb-41e6-ac7a-aec5efde10b3
Ramnarine, Kumar V.
ace822bc-da10-4bbf-bf10-2f4746715da4
Chung, Emma M.L.
2a4bf9d7-6ed4-4726-94aa-a57d6fd78b3e
27 July 2023
Nicholls, Jennifer K.
89678848-ffe5-4157-8bfc-cc495babaa09
Turner, Poppy
4de775aa-83e7-4314-a367-d73a580e8226
Lecchini-Visintini, Andrea
23cc1428-c307-4fba-b171-cb3f53ba8c80
Ince, Jonathan
55157657-56bb-45ef-b67c-1ff1c23ab4dd
de Vries, Georgina
b5d1861f-c0e5-4506-b508-e69e54dc7cbb
Cappellugola, Laurie
a864c3ad-1640-409f-84c5-95b1a31963b9
Oura, Mitsuhiro
8118dd55-12b5-4161-bc66-c3cc54630f10
Ebirim, Kelechi U.
244d469b-dcb5-44c2-9597-371035b5167d
Pallett, Edward
60654e18-a8cb-41e6-ac7a-aec5efde10b3
Ramnarine, Kumar V.
ace822bc-da10-4bbf-bf10-2f4746715da4
Chung, Emma M.L.
2a4bf9d7-6ed4-4726-94aa-a57d6fd78b3e
Nicholls, Jennifer K., Turner, Poppy, Lecchini-Visintini, Andrea, Ince, Jonathan, de Vries, Georgina, Cappellugola, Laurie, Oura, Mitsuhiro, Ebirim, Kelechi U., Pallett, Edward, Ramnarine, Kumar V. and Chung, Emma M.L.
(2023)
Effects of blood pressure on brain tissue pulsation amplitude in a phantom model.
Ultrasound in Medicine & Biology, 49 (9), .
(doi:10.1016/j.ultrasmedbio.2023.06.005).
Abstract
Objective: the precise mechanism and determinants of brain tissue pulsations (BTPs) are poorly understood, and the impact of blood pressure (BP) on BTPs is relatively unexplored. This study aimed to explore the relationship between BP parameters (mean arterial pressure [MAP] and pulse pressure [PP]) and BTP amplitude, using a transcranial tissue Doppler prototype.
Methods: a phantom brain model generating arterial-induced BTPs was developed to observe BP changes in the absence of confounding variables and cerebral autoregulation feedback processes. A regression model was developed to investigate the relationship between bulk BTP amplitude and BP. The separate effects of PP and MAP were evaluated and quantified.
Results: the regression model (R2 = 0.978) revealed that bulk BTP amplitude measured from 27 gates significantly increased with PP but not with MAP. Every 1 mm Hg increase in PP resulted in a bulk BTP amplitude increase of 0.29 µm.
Conclusion: increments in BP were significantly associated with increments in bulk BTP amplitude. Further work should aim to confirm the relationship between BP and BTPs in the presence of cerebral autoregulation and explore further physiological factors having an impact on BTP measurements, such as cerebral blood flow volume, tissue distensibility and intracranial pressure.
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Accepted/In Press date: 7 June 2023
e-pub ahead of print date: 1 July 2023
Published date: 27 July 2023
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Local EPrints ID: 491759
URI: http://eprints.soton.ac.uk/id/eprint/491759
ISSN: 0301-5629
PURE UUID: b3c17a84-2477-41a0-a8dd-3caaa7af5698
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Date deposited: 03 Jul 2024 17:14
Last modified: 11 Jul 2024 04:40
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Contributors
Author:
Jennifer K. Nicholls
Author:
Poppy Turner
Author:
Andrea Lecchini-Visintini
Author:
Jonathan Ince
Author:
Georgina de Vries
Author:
Laurie Cappellugola
Author:
Mitsuhiro Oura
Author:
Kelechi U. Ebirim
Author:
Edward Pallett
Author:
Kumar V. Ramnarine
Author:
Emma M.L. Chung
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