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Uptake of multi-level HIV interventions and HIV-related behaviours among young people in rural South Africa

Uptake of multi-level HIV interventions and HIV-related behaviours among young people in rural South Africa
Uptake of multi-level HIV interventions and HIV-related behaviours among young people in rural South Africa

Combination HIV prevention packages have reduced HIV incidence and improved HIVrelated outcomes among young people. However, there is limited data on how package components interact to promote HIV-related prevention behaviours. We described the uptake of HIV prevention interventions supported by Determined, Resilient, Empowered, AIDS-free, Motivated and Safe (DREAMS) Partnership and assessed the association between uptake and HIV-related behaviours among young people in rural KwaZulu-Natal, South Africa. We analysed two cohorts followed from May 2017 to December 2019 to evaluate the impact of DREAMS, covering 13-29 year-old females, and 13-35 year-old males. DREAMS interventions were categorised as healthcare-based or social. We described the uptake of interventions and ran logistic regression models to investigate the association between intervention uptake and subsequent protective HIV-related outcomes including no condomless sex and voluntary medical male circumcision (VMMC). For each outcome, we adjusted for sociodemographics and sexual/pregnancy history and reported adjusted odds ratios (aOR) and 95% confidence intervals (CI). Among 5248 participants, uptake of healthcare interventions increased from 2018 to 2019 by 8.1% and 3.7% for males and females respectively; about half of participants reported receiving both healthcare and social interventions each year. The most utilised combinations of interventions included HIV testing and counselling, schoolbased HIV education and cash transfers. Participation in social interventions only compared to no intervention was associated with reduced condomless sex (aOR = 1.60, 95%CI: 1.03- 2.47), while participation in healthcare interventions only was associated with increased condomless sex. The uptake of interventions did not significantly affect subsequent VMMC overall. Among adolescent boys, exposure to school-based HIV education, cash transfers and HIV testing and counselling was associated with increase in VMMC (aOR = 1.79, 95% CI: 1.04-3.07). Multi-level HIV prevention interventions were associated with an increase in protective HIV-related behaviours emphasizing the importance of accessible programs within both school and community settings for young people.

2767-3375
Mthiyane, Nondumiso
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Shahmanesh, Maryam
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Copas, Andrew
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Chimbindi, Natsayi
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Dreyer, Jaco
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Zuma, Thembelihle
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McGrath, Nuala
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Baisley, Kathy
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Floyd, Sian
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Birdthistle, Isolde
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Sherr, Lorraine
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Seeley, Janet
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Harling, Guy
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Mthiyane, Nondumiso
690c6e97-3df8-4d43-8d9d-9ab580369fd4
Shahmanesh, Maryam
d88581c9-0ef2-4506-b8d3-d72682936a09
Copas, Andrew
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Chimbindi, Natsayi
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Dreyer, Jaco
66cdb4a4-0837-4f68-bcc0-c903f1e10b9b
Zuma, Thembelihle
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McGrath, Nuala
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Baisley, Kathy
5fe8c276-d9d2-4bb6-91a3-8acd38a5151f
Floyd, Sian
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Birdthistle, Isolde
de32dd88-7206-4bc3-9cb9-b86f15707cfa
Sherr, Lorraine
dcc07842-49e3-44fc-bf87-d56dd0f15323
Seeley, Janet
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Harling, Guy
0403b83a-0afe-472c-a184-7a6357afe29a

Mthiyane, Nondumiso, Shahmanesh, Maryam, Copas, Andrew, Chimbindi, Natsayi, Dreyer, Jaco, Zuma, Thembelihle, McGrath, Nuala, Baisley, Kathy, Floyd, Sian, Birdthistle, Isolde, Sherr, Lorraine, Seeley, Janet and Harling, Guy (2024) Uptake of multi-level HIV interventions and HIV-related behaviours among young people in rural South Africa. PLOS Global Public Health, 4 (5), [e0003258]. (doi:10.1371/journal.pgph.0003258).

Record type: Article

Abstract

Combination HIV prevention packages have reduced HIV incidence and improved HIVrelated outcomes among young people. However, there is limited data on how package components interact to promote HIV-related prevention behaviours. We described the uptake of HIV prevention interventions supported by Determined, Resilient, Empowered, AIDS-free, Motivated and Safe (DREAMS) Partnership and assessed the association between uptake and HIV-related behaviours among young people in rural KwaZulu-Natal, South Africa. We analysed two cohorts followed from May 2017 to December 2019 to evaluate the impact of DREAMS, covering 13-29 year-old females, and 13-35 year-old males. DREAMS interventions were categorised as healthcare-based or social. We described the uptake of interventions and ran logistic regression models to investigate the association between intervention uptake and subsequent protective HIV-related outcomes including no condomless sex and voluntary medical male circumcision (VMMC). For each outcome, we adjusted for sociodemographics and sexual/pregnancy history and reported adjusted odds ratios (aOR) and 95% confidence intervals (CI). Among 5248 participants, uptake of healthcare interventions increased from 2018 to 2019 by 8.1% and 3.7% for males and females respectively; about half of participants reported receiving both healthcare and social interventions each year. The most utilised combinations of interventions included HIV testing and counselling, schoolbased HIV education and cash transfers. Participation in social interventions only compared to no intervention was associated with reduced condomless sex (aOR = 1.60, 95%CI: 1.03- 2.47), while participation in healthcare interventions only was associated with increased condomless sex. The uptake of interventions did not significantly affect subsequent VMMC overall. Among adolescent boys, exposure to school-based HIV education, cash transfers and HIV testing and counselling was associated with increase in VMMC (aOR = 1.79, 95% CI: 1.04-3.07). Multi-level HIV prevention interventions were associated with an increase in protective HIV-related behaviours emphasizing the importance of accessible programs within both school and community settings for young people.

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Accepted/In Press date: 1 May 2024
Published date: 31 May 2024
Additional Information: For the purpose of open access, the author has applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission.

Identifiers

Local EPrints ID: 491776
URI: http://eprints.soton.ac.uk/id/eprint/491776
ISSN: 2767-3375
PURE UUID: d19c1451-d7c4-403c-a192-e8cd8aacdf6a
ORCID for Nuala McGrath: ORCID iD orcid.org/0000-0002-1039-0159

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Date deposited: 03 Jul 2024 17:28
Last modified: 12 Jul 2024 01:50

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Contributors

Author: Nondumiso Mthiyane
Author: Maryam Shahmanesh
Author: Andrew Copas
Author: Natsayi Chimbindi
Author: Jaco Dreyer
Author: Thembelihle Zuma
Author: Nuala McGrath ORCID iD
Author: Kathy Baisley
Author: Sian Floyd
Author: Isolde Birdthistle
Author: Lorraine Sherr
Author: Janet Seeley
Author: Guy Harling

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