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Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Macrophages and microglia in the developing and adult mouse brain have been identified by is consistent with the idea that dying neurons and axons provide a stimulus for macrophage infiltration. Our results provide strong support for the hypothesis that the microglia are derived from monocytes and show that microglia possess receptors which would allow them to play a part in the immune defence of the nervous system.

0306-4522
313-326
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Hume, D.A.
dd2085e5-83d3-454a-9e68-9391c09133a4
Gordon, S.
df664ae8-6319-4b1a-8f16-49f4a5fe760f
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Hume, D.A.
dd2085e5-83d3-454a-9e68-9391c09133a4
Gordon, S.
df664ae8-6319-4b1a-8f16-49f4a5fe760f

Perry, V.H., Hume, D.A. and Gordon, S. (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience, 15 (2), 313-326. (doi:10.1016/0306-4522(85)90215-5).

Record type: Article

Abstract

Macrophages and microglia in the developing and adult mouse brain have been identified by is consistent with the idea that dying neurons and axons provide a stimulus for macrophage infiltration. Our results provide strong support for the hypothesis that the microglia are derived from monocytes and show that microglia possess receptors which would allow them to play a part in the immune defence of the nervous system.

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More information

Accepted/In Press date: 7 December 1984
Published date: June 1985
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Identifiers

Local EPrints ID: 491792
URI: http://eprints.soton.ac.uk/id/eprint/491792
DOI: doi:10.1016/0306-4522(85)90215-5
ISSN: 0306-4522
PURE UUID: d1e97eeb-e5a6-4996-ac06-851426105cd7

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Date deposited: 04 Jul 2024 16:38
Last modified: 10 Jul 2024 20:04

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Contributors

Author: V.H. Perry
Author: D.A. Hume
Author: S. Gordon

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