Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies
Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular mechanisms contributing to the altered regulation of muscle protein balance during disuse have been investigated but rarely synthesised in the context of humans. This narrative review discusses human models of muscle disuse and the ensuing inversely exponential rate of muscle atrophy. The molecular processes contributing to altered protein balance are explored, with a particular focus on growth and breakdown signalling pathways, mitochondrial adaptations and neuromuscular dysfunction. Finally, key research gaps within the disuse atrophy literature are highlighted providing future avenues to enhance our mechanistic understanding of human disuse atrophy.
Humans, Immobilization/adverse effects, Muscle Proteins/metabolism, Muscle, Skeletal/metabolism, Muscular Atrophy/metabolism, Muscular Disorders, Atrophic/metabolism, Signal Transduction, atrophy, disuse, skeletal muscle
741-756
Deane, Colleen S.
3320532e-f411-4ea8-9a14-4a9f248da898
Piasecki, Matthew
398d0d95-4de1-4efa-bc86-c22051e589d0
Atherton, Philip J.
b9c1604a-deaa-4174-8b72-e564dd72dd68
19 June 2024
Deane, Colleen S.
3320532e-f411-4ea8-9a14-4a9f248da898
Piasecki, Matthew
398d0d95-4de1-4efa-bc86-c22051e589d0
Atherton, Philip J.
b9c1604a-deaa-4174-8b72-e564dd72dd68
Deane, Colleen S., Piasecki, Matthew and Atherton, Philip J.
(2024)
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies.
Clinical Science, 138 (12), .
(doi:10.1042/CS20231198).
Abstract
Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular mechanisms contributing to the altered regulation of muscle protein balance during disuse have been investigated but rarely synthesised in the context of humans. This narrative review discusses human models of muscle disuse and the ensuing inversely exponential rate of muscle atrophy. The molecular processes contributing to altered protein balance are explored, with a particular focus on growth and breakdown signalling pathways, mitochondrial adaptations and neuromuscular dysfunction. Finally, key research gaps within the disuse atrophy literature are highlighted providing future avenues to enhance our mechanistic understanding of human disuse atrophy.
Text
cs-2023-1198c
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Accepted/In Press date: 4 June 2024
Published date: 19 June 2024
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© 2024 The Author(s).
Keywords:
Humans, Immobilization/adverse effects, Muscle Proteins/metabolism, Muscle, Skeletal/metabolism, Muscular Atrophy/metabolism, Muscular Disorders, Atrophic/metabolism, Signal Transduction, atrophy, disuse, skeletal muscle
Identifiers
Local EPrints ID: 491844
URI: http://eprints.soton.ac.uk/id/eprint/491844
ISSN: 0143-5221
PURE UUID: bf9a3b90-7f5a-4550-b6c0-b1d45448e8b9
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Date deposited: 04 Jul 2024 17:04
Last modified: 12 Jul 2024 02:12
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Contributors
Author:
Colleen S. Deane
Author:
Matthew Piasecki
Author:
Philip J. Atherton
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