Genetics of gambling disorder and related phenotypes: the potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes
Genetics of gambling disorder and related phenotypes: the potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes
Gambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.
early diagnosis, early intervention, multifactorial risk scores, polygenic risk scores, problem gambling
16-20
Warrier, Varun
767575f7-d01c-4040-985c-5943bb172a8f
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Thomas, Shane A.
f957d444-eb0e-4c72-a412-64eec0eb7d10
Bowden-Jones, Henrietta
8422a458-cdd1-49b4-918e-ead577eea66c
26 March 2024
Warrier, Varun
767575f7-d01c-4040-985c-5943bb172a8f
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Thomas, Shane A.
f957d444-eb0e-4c72-a412-64eec0eb7d10
Bowden-Jones, Henrietta
8422a458-cdd1-49b4-918e-ead577eea66c
Warrier, Varun, Chamberlain, Samuel R., Thomas, Shane A. and Bowden-Jones, Henrietta
(2024)
Genetics of gambling disorder and related phenotypes: the potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes.
JOURNAL OF BEHAVIORAL ADDICTIONS, 13 (1), .
(doi:10.1556/2006.2023.00075).
Abstract
Gambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.
Text
2006-article-p16
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More information
Accepted/In Press date: 3 December 2023
e-pub ahead of print date: 15 January 2024
Published date: 26 March 2024
Keywords:
early diagnosis, early intervention, multifactorial risk scores, polygenic risk scores, problem gambling
Identifiers
Local EPrints ID: 491893
URI: http://eprints.soton.ac.uk/id/eprint/491893
ISSN: 2062-5871
PURE UUID: dbcd2eaf-c5f9-439d-87c5-4bd56dc19c5b
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Date deposited: 05 Jul 2024 16:43
Last modified: 12 Jul 2024 02:06
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Contributors
Author:
Varun Warrier
Author:
Samuel R. Chamberlain
Author:
Shane A. Thomas
Author:
Henrietta Bowden-Jones
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