Response of refractory gambling disorder to intravenous ketamine
Response of refractory gambling disorder to intravenous ketamine
Gambling disorder is a disabling condition with a lifetime prevalence of around 2% in the United States. It results in psychosocial impairment, financial and family problems, and elevated rates of suicide. Current treatments for gambling disorder include cognitive-behavioral therapy and opioid antagonists, but these treatments are often difficult for patients to access. By decreasing the incentive-motivational value of reward-related cues via antagonism of N-methyl-d-aspartate receptors in the prefrontal cortex and mesolimbic regions, ketamine merits consideration as a candidate treatment for gambling disorder, and its use may yield valuable information about the brain regions implicated in the pathophysiology of problematic gambling behaviors. We hereby present a case of gambling disorder that responded to intravenous ketamine.
Grant, Jon E.
68b74bfc-0910-4325-aa34-24d285abfc19
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
16 January 2020
Grant, Jon E.
68b74bfc-0910-4325-aa34-24d285abfc19
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Grant, Jon E. and Chamberlain, Samuel R.
(2020)
Response of refractory gambling disorder to intravenous ketamine.
Primary Care Companion for CNS Disorders, 22 (1), [19l02480].
(doi:10.4088/PCC.19l02480).
Abstract
Gambling disorder is a disabling condition with a lifetime prevalence of around 2% in the United States. It results in psychosocial impairment, financial and family problems, and elevated rates of suicide. Current treatments for gambling disorder include cognitive-behavioral therapy and opioid antagonists, but these treatments are often difficult for patients to access. By decreasing the incentive-motivational value of reward-related cues via antagonism of N-methyl-d-aspartate receptors in the prefrontal cortex and mesolimbic regions, ketamine merits consideration as a candidate treatment for gambling disorder, and its use may yield valuable information about the brain regions implicated in the pathophysiology of problematic gambling behaviors. We hereby present a case of gambling disorder that responded to intravenous ketamine.
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Published date: 16 January 2020
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Local EPrints ID: 492139
URI: http://eprints.soton.ac.uk/id/eprint/492139
ISSN: 2155-7772
PURE UUID: 0bc99095-5119-4c19-8c51-efa059bf28a3
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Date deposited: 17 Jul 2024 17:01
Last modified: 20 Jul 2024 02:02
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Author:
Jon E. Grant
Author:
Samuel R. Chamberlain
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