Modelling the effects of charge on antibiotic diffusion and adsorption in liquid crystalline virus suspensions
Modelling the effects of charge on antibiotic diffusion and adsorption in liquid crystalline virus suspensions
We develop a microscopic model of antibiotic diffusion in virus suspensions in a liquid crystalline state. We then approximate this with an effective homogenised model that is more amenable to analytical investigation, to understand the effect of charge on the antibiotic tolerance. We show that liquid crystalline virus suspensions slow down antibiotics significantly, and that electric charge strongly contributes to this by influencing the effective diameter and adsorptive capacity of the liquid crystalline viruses so that charged antibiotics diffuse much slower than neutral ones; this can be directly and efficiently derived from the homogenised model and is in good agreement with experiments in microbiology. Charge is also found to affect the relationship between antibiotic diffusion and viral packing density in a nontrivial way. The results elucidate the effect of charge on antibiotic tolerance in liquid crystalline biofilms in a manner that is straightforwardly extendable to other soft matter systems.
van Rossem, Maria Tessel
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Wilks, Sandra
86c1f41a-12b3-451c-9245-b1a21775e993
Kaczmarek, Malgosia
408ec59b-8dba-41c1-89d0-af846d1bf327
D'Alessandro, Giampaolo
bad097e1-9506-4b6e-aa56-3e67a526e83b
van Rossem, Maria Tessel
7f83bf9e-7375-4056-8d30-6e1552e77d9f
Wilks, Sandra
86c1f41a-12b3-451c-9245-b1a21775e993
Kaczmarek, Malgosia
408ec59b-8dba-41c1-89d0-af846d1bf327
D'Alessandro, Giampaolo
bad097e1-9506-4b6e-aa56-3e67a526e83b
van Rossem, Maria Tessel, Wilks, Sandra, Kaczmarek, Malgosia and D'Alessandro, Giampaolo
(2024)
Modelling the effects of charge on antibiotic diffusion and adsorption in liquid crystalline virus suspensions.
Soft Matter.
(doi:10.1039/d4sm00349g).
Abstract
We develop a microscopic model of antibiotic diffusion in virus suspensions in a liquid crystalline state. We then approximate this with an effective homogenised model that is more amenable to analytical investigation, to understand the effect of charge on the antibiotic tolerance. We show that liquid crystalline virus suspensions slow down antibiotics significantly, and that electric charge strongly contributes to this by influencing the effective diameter and adsorptive capacity of the liquid crystalline viruses so that charged antibiotics diffuse much slower than neutral ones; this can be directly and efficiently derived from the homogenised model and is in good agreement with experiments in microbiology. Charge is also found to affect the relationship between antibiotic diffusion and viral packing density in a nontrivial way. The results elucidate the effect of charge on antibiotic tolerance in liquid crystalline biofilms in a manner that is straightforwardly extendable to other soft matter systems.
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d4sm00349g
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Accepted/In Press date: 16 July 2024
e-pub ahead of print date: 18 July 2024
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Local EPrints ID: 492496
URI: http://eprints.soton.ac.uk/id/eprint/492496
ISSN: 1744-683X
PURE UUID: e8eb0861-fa52-40ce-83bd-9bebd06a427f
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Date deposited: 30 Jul 2024 16:34
Last modified: 06 Aug 2024 01:35
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Author:
Maria Tessel van Rossem
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