Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology
Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology
Cardiovascular disease is the leading cause of death worldwide. Dual antiplatelet therapy (DAPT), with aspirin plus a P2Y12 inhibitor, is currently recommended as a default for patients after acute coronary syndrome (ACS) and following percutaneous coronary intervention (PCI). However, controversies arise over the role of aspirin, the optimal duration of DAPT after drug-eluting stent (DES) implantation, the choice of P2Y12 inhibitor and the variability in individual responses to antiplatelet agents. Recent data indicate that monotherapy with a P2Y12 inhibitor may have adequate anti-ischemic effects with lower bleeding risk. Additionally, discrepancies in DAPT duration recommendations and the optimal P2Y12 inhibitor, provides more uncertainty. We ask the question “does one size really fits all?” or should a more personalized strategy should be implemented.
CYP2C19 LOF, TEG 6S, acute coronary syndrome, antiplatelets, genotype, ischemic heart disease, personalized antiplatelet therapy, phenotype, platelet function testing
Elserwey, Ahmed
860ab4e4-973f-4a5e-8de4-ce904d2ba65c
Jabbour, Richard J.
fc38a4f8-18fe-4dd5-987d-47dfee7e1929
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Elserwey, Ahmed
860ab4e4-973f-4a5e-8de4-ce904d2ba65c
Jabbour, Richard J.
fc38a4f8-18fe-4dd5-987d-47dfee7e1929
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Elserwey, Ahmed, Jabbour, Richard J. and Curzen, Nick
(2024)
Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology.
Future Cardiology.
(doi:10.1080/14796678.2024.2384217).
Abstract
Cardiovascular disease is the leading cause of death worldwide. Dual antiplatelet therapy (DAPT), with aspirin plus a P2Y12 inhibitor, is currently recommended as a default for patients after acute coronary syndrome (ACS) and following percutaneous coronary intervention (PCI). However, controversies arise over the role of aspirin, the optimal duration of DAPT after drug-eluting stent (DES) implantation, the choice of P2Y12 inhibitor and the variability in individual responses to antiplatelet agents. Recent data indicate that monotherapy with a P2Y12 inhibitor may have adequate anti-ischemic effects with lower bleeding risk. Additionally, discrepancies in DAPT duration recommendations and the optimal P2Y12 inhibitor, provides more uncertainty. We ask the question “does one size really fits all?” or should a more personalized strategy should be implemented.
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Accepted/In Press date: 22 July 2024
e-pub ahead of print date: 2 August 2024
Keywords:
CYP2C19 LOF, TEG 6S, acute coronary syndrome, antiplatelets, genotype, ischemic heart disease, personalized antiplatelet therapy, phenotype, platelet function testing
Identifiers
Local EPrints ID: 492655
URI: http://eprints.soton.ac.uk/id/eprint/492655
ISSN: 1479-6678
PURE UUID: 8a8c5c17-6f88-401d-b7f0-7f1d6aa9a58d
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Date deposited: 09 Aug 2024 16:45
Last modified: 14 Aug 2024 01:40
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Author:
Ahmed Elserwey
Author:
Richard J. Jabbour
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