Using event-related potentials to characterize inhibitory control and self-monitoring across impulsive and compulsive phenotypes: a dimensional approach to OCD
Using event-related potentials to characterize inhibitory control and self-monitoring across impulsive and compulsive phenotypes: a dimensional approach to OCD
Objective Subsyndromal obsessive-compulsive disorder symptoms (OCDSs) are common and cause impaired psychosocial functioning. OCDSs are better captured by dimensional models of psychopathology, as opposed to categorical diagnoses. However, such dimensional approaches require a deep understanding of the underlying neurocognitive drivers and impulsive and compulsive traits (ie, neurocognitive phenotypes) across symptoms. This study investigated inhibitory control and self-monitoring across impulsivity, compulsivity, and their interaction in individuals (n = 40) experiencing mild-moderate OCDSs. Methods EEG recording concurrent with the stop-signal task was used to elicit event-related potentials (ERPs) indexing inhibitory control (ie, N2 and P3) and self-monitoring (ie, error-related negativity and correct-related negativity (CRN): negativity following erroneous or correct responses, respectively). Results During unsuccessful stopping, individuals high in both impulsivity and compulsivity displayed enhanced N2 amplitude, indicative of conflict between the urge to respond and need to stop (F(3, 33) = 1.48, P <.05, 95% Cl [-0.01, 0.001]). Individuals high in compulsivity and low in impulsivity showed reduced P3 amplitude, consistent with impairments in monitoring failed inhibitory control (F(3, 24) = 2.033, P <.05, 95% CI [-0.002, 0.045]). Following successful stopping, high compulsivity (independent of impulsivity) was associated with lower CRN amplitude, reflecting hypo-monitoring of correct responses (F(4, 32) = 4.76, P <.05, 95% CI [0.01, 0.02]), and with greater OCDS severity (F(3, 36) = 3.32, P <.05, 95% CI [0.03, 0.19]). Conclusion The current findings provide evidence for differential, ERP-indexed inhibitory control and self-monitoring profiles across impulsive and compulsive phenotypes in OCDSs.
compulsivity, CRN, ERN, Impulsivity, inhibitory control, N2, P3, phenotyping, self-monitoring
331-342
Dhir, Sakshi
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Tyler, Kaelasha
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Albertella, Lucy
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Chamberlain, Samuel R.
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Teo, Wei Peng
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Yücel, Murat
aff092ea-35e0-476a-b9bf-ace9b84aa1e1
Segrave, Rebecca A.
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Dhir, Sakshi
c4345e15-babe-4a88-b89f-761a1216a4c4
Tyler, Kaelasha
d190122e-8890-4c5b-9d77-4919fac57c06
Albertella, Lucy
c95a7a69-10d8-4549-a155-55a42170d8c0
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Teo, Wei Peng
c1a99f56-f862-43f2-9656-a41033715b15
Yücel, Murat
aff092ea-35e0-476a-b9bf-ace9b84aa1e1
Segrave, Rebecca A.
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Dhir, Sakshi, Tyler, Kaelasha, Albertella, Lucy, Chamberlain, Samuel R., Teo, Wei Peng, Yücel, Murat and Segrave, Rebecca A.
(2023)
Using event-related potentials to characterize inhibitory control and self-monitoring across impulsive and compulsive phenotypes: a dimensional approach to OCD.
CNS Spectrums, 28 (3), .
(doi:10.1017/S109285292200075X).
Abstract
Objective Subsyndromal obsessive-compulsive disorder symptoms (OCDSs) are common and cause impaired psychosocial functioning. OCDSs are better captured by dimensional models of psychopathology, as opposed to categorical diagnoses. However, such dimensional approaches require a deep understanding of the underlying neurocognitive drivers and impulsive and compulsive traits (ie, neurocognitive phenotypes) across symptoms. This study investigated inhibitory control and self-monitoring across impulsivity, compulsivity, and their interaction in individuals (n = 40) experiencing mild-moderate OCDSs. Methods EEG recording concurrent with the stop-signal task was used to elicit event-related potentials (ERPs) indexing inhibitory control (ie, N2 and P3) and self-monitoring (ie, error-related negativity and correct-related negativity (CRN): negativity following erroneous or correct responses, respectively). Results During unsuccessful stopping, individuals high in both impulsivity and compulsivity displayed enhanced N2 amplitude, indicative of conflict between the urge to respond and need to stop (F(3, 33) = 1.48, P <.05, 95% Cl [-0.01, 0.001]). Individuals high in compulsivity and low in impulsivity showed reduced P3 amplitude, consistent with impairments in monitoring failed inhibitory control (F(3, 24) = 2.033, P <.05, 95% CI [-0.002, 0.045]). Following successful stopping, high compulsivity (independent of impulsivity) was associated with lower CRN amplitude, reflecting hypo-monitoring of correct responses (F(4, 32) = 4.76, P <.05, 95% CI [0.01, 0.02]), and with greater OCDS severity (F(3, 36) = 3.32, P <.05, 95% CI [0.03, 0.19]). Conclusion The current findings provide evidence for differential, ERP-indexed inhibitory control and self-monitoring profiles across impulsive and compulsive phenotypes in OCDSs.
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using-event-related-potentials-to-characterize-inhibitory-control-and-self-monitoring-across-impulsive-and-compulsive-phenotypes-a-dimensional-approach-to-ocd
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Accepted/In Press date: 28 March 2022
e-pub ahead of print date: 29 June 2023
Additional Information:
For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission.
Keywords:
compulsivity, CRN, ERN, Impulsivity, inhibitory control, N2, P3, phenotyping, self-monitoring
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Local EPrints ID: 492715
URI: http://eprints.soton.ac.uk/id/eprint/492715
ISSN: 1092-8529
PURE UUID: 1b3a6270-2164-412e-864f-f91802616d7d
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Date deposited: 12 Aug 2024 16:48
Last modified: 13 Aug 2024 01:58
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Contributors
Author:
Sakshi Dhir
Author:
Kaelasha Tyler
Author:
Lucy Albertella
Author:
Samuel R. Chamberlain
Author:
Wei Peng Teo
Author:
Murat Yücel
Author:
Rebecca A. Segrave
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