Obsessive compulsive disorders
Obsessive compulsive disorders
Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric condition. Relatively little, however, is understood about the etiology and brain basis of OCD despite decades of research. Although neuroimaging findings in OCD frequently report abnormalities of the orbitofrontal cortex, anterior cingulate cortex, and caudate nucleus, new insights into the disorder are urgently needed. In this chapter, we review the current state of this evidence, including neuroimaging studies, genetics, neurochemical investigations, and insights from animal models.
Animal models, Dopamine, Genome wide association studies, Glutamate, History, HPA axis, Hypothalamic-pituitary-adrenal (HPA) axis, Immune system, Neuroanatomical circuits, Neurocognition, Neurotransmitter systems, Obsessive-compulsive disorder (OCD), Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), Serotonin
4497-4504
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
18 October 2022
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Grant, Jon E. and Chamberlain, Samuel R.
(2022)
Obsessive compulsive disorders.
In,
Pfaff, Donald W., Volkow, Nora D. and Rubenstein, John L.
(eds.)
Neuroscience in the 21st Century: From Basic to Clinical.
3 ed.
Springer Cham, .
(doi:10.1007/978-3-030-88832-9_160).
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Book Section
Abstract
Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric condition. Relatively little, however, is understood about the etiology and brain basis of OCD despite decades of research. Although neuroimaging findings in OCD frequently report abnormalities of the orbitofrontal cortex, anterior cingulate cortex, and caudate nucleus, new insights into the disorder are urgently needed. In this chapter, we review the current state of this evidence, including neuroimaging studies, genetics, neurochemical investigations, and insights from animal models.
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Published date: 18 October 2022
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© Springer Science+Business Media New York 2013, 2016 and Springer Nature Switzerland AG 2022.
Keywords:
Animal models, Dopamine, Genome wide association studies, Glutamate, History, HPA axis, Hypothalamic-pituitary-adrenal (HPA) axis, Immune system, Neuroanatomical circuits, Neurocognition, Neurotransmitter systems, Obsessive-compulsive disorder (OCD), Pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), Serotonin
Identifiers
Local EPrints ID: 492739
URI: http://eprints.soton.ac.uk/id/eprint/492739
PURE UUID: 627bf2bb-7ad4-4503-850b-70af52f08807
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Date deposited: 13 Aug 2024 16:40
Last modified: 14 Aug 2024 02:00
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Contributors
Author:
Jon E. Grant
Author:
Samuel R. Chamberlain
Editor:
Donald W. Pfaff
Editor:
Nora D. Volkow
Editor:
John L. Rubenstein
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