Obsessive-compulsive disorder: etiology, neuropathology, and cognitive dysfunction
Obsessive-compulsive disorder: etiology, neuropathology, and cognitive dysfunction
Background: this review provides an overview of obsessive-compulsive disorder (OCD) symptoms, including the four partially distinct subtypes of the disorder, current diagnostic criteria, and common comorbidities. Critically, it focuses on the etiology of OCD, including its underlying neuropathology, and examines cognitive dysfunction in OCD.
Methods: this review study was conducted by library method.
Results: we show how dysfunction in cortico-striato-thalamo-cortical (CSTC) circuits may underpin symptoms; and shed light on the putative neurochemistry within these loops such as the role of serotonin, dopamine, and glutamate systems. We also show how OCD is characterized by cognitive dysfunction including problems in cognitive flexibility, visuospatial memory, response inhibition, and goal-directed behavior, linked to aberrant activity within CSTC circuits.
Conclusions: in brief, research questions we shed light on include (1) what are the symptoms in OCD; (2) what is the etiology of the disorder and do existing models explain OCD; and (3) what are key cognitive deficits in OCD and do these improve with treatment?.
cognitive function, cognitive models, etiology, learning-based models, neuropathology, obsessive-compulsive disorder
Jalal, Baland
0c83971a-9a5c-4107-b1e3-c54eac837819
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Sahakian, Barbara J.
e689cd5c-b84f-4503-86ca-7526cf340121
16 June 2023
Jalal, Baland
0c83971a-9a5c-4107-b1e3-c54eac837819
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Sahakian, Barbara J.
e689cd5c-b84f-4503-86ca-7526cf340121
Jalal, Baland, Chamberlain, Samuel R. and Sahakian, Barbara J.
(2023)
Obsessive-compulsive disorder: etiology, neuropathology, and cognitive dysfunction.
Brain and Behavior, 13 (6), [e3000].
(doi:10.1002/brb3.3000).
Abstract
Background: this review provides an overview of obsessive-compulsive disorder (OCD) symptoms, including the four partially distinct subtypes of the disorder, current diagnostic criteria, and common comorbidities. Critically, it focuses on the etiology of OCD, including its underlying neuropathology, and examines cognitive dysfunction in OCD.
Methods: this review study was conducted by library method.
Results: we show how dysfunction in cortico-striato-thalamo-cortical (CSTC) circuits may underpin symptoms; and shed light on the putative neurochemistry within these loops such as the role of serotonin, dopamine, and glutamate systems. We also show how OCD is characterized by cognitive dysfunction including problems in cognitive flexibility, visuospatial memory, response inhibition, and goal-directed behavior, linked to aberrant activity within CSTC circuits.
Conclusions: in brief, research questions we shed light on include (1) what are the symptoms in OCD; (2) what is the etiology of the disorder and do existing models explain OCD; and (3) what are key cognitive deficits in OCD and do these improve with treatment?.
Text
Brain and Behavior - 2023 - Jalal - Obsessive‐compulsive disorder Etiology neuropathology and cognitive dysfunction
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More information
Accepted/In Press date: 24 March 2023
e-pub ahead of print date: 3 May 2023
Published date: 16 June 2023
Keywords:
cognitive function, cognitive models, etiology, learning-based models, neuropathology, obsessive-compulsive disorder
Identifiers
Local EPrints ID: 492862
URI: http://eprints.soton.ac.uk/id/eprint/492862
ISSN: 2162-3279
PURE UUID: db0dfe12-c442-4833-8276-2bb61a37a275
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Date deposited: 16 Aug 2024 16:54
Last modified: 17 Aug 2024 02:06
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Contributors
Author:
Baland Jalal
Author:
Samuel R. Chamberlain
Author:
Barbara J. Sahakian
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