Noradrenergic modulation of cognition: Therapeutic implications
Noradrenergic modulation of cognition: Therapeutic implications
The noradrenaline (norepinephrine) system exerts profound influences on cognition via ascending projections to the forebrain, mostly originating from the locus coeruleus. This paper provides an overview of available infrahuman and healthy human studies, exploring the effects of specific noradrenergic manipulations on dissociable cognitive functions, including attention, working memory, cognitive flexibility, response inhibition and emotional memory. Remarkable parallels across species have been reported which may account for the mechanisms by which noradrenergic medications exert their beneficial effects in disorders such as depression and attention-deficit hyperactivity disorder (ADHD). The literature is discussed in relation to prevailing models of noradrenergic influences over cognition and novel therapeutic directions, including in relation to investigating the effects of noradrenergic manipulations on other disorders characterized by impulsivity, and dementias. Unanswered questions are also highlighted, along with key avenues for future research, both proof-of-concept and clinical.
attention, cognition, cognitive flexibility, emotional memory, inhibition, Intra-Dimensional / Extra-Dimensional, Intra-Dimensional Extra-Dimensional, locus coeruleus, modulation, Noradrenaline, norepinephrine, translational, working memory
694-718
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Robbins, Trevor W.
20dd57dd-dbf3-4aaa-b7ba-bb4387ffcbc7
August 2013
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Robbins, Trevor W.
20dd57dd-dbf3-4aaa-b7ba-bb4387ffcbc7
Chamberlain, Samuel R. and Robbins, Trevor W.
(2013)
Noradrenergic modulation of cognition: Therapeutic implications.
Journal of Psychopharmacology, 27 (8), .
(doi:10.1177/0269881113480988).
Abstract
The noradrenaline (norepinephrine) system exerts profound influences on cognition via ascending projections to the forebrain, mostly originating from the locus coeruleus. This paper provides an overview of available infrahuman and healthy human studies, exploring the effects of specific noradrenergic manipulations on dissociable cognitive functions, including attention, working memory, cognitive flexibility, response inhibition and emotional memory. Remarkable parallels across species have been reported which may account for the mechanisms by which noradrenergic medications exert their beneficial effects in disorders such as depression and attention-deficit hyperactivity disorder (ADHD). The literature is discussed in relation to prevailing models of noradrenergic influences over cognition and novel therapeutic directions, including in relation to investigating the effects of noradrenergic manipulations on other disorders characterized by impulsivity, and dementias. Unanswered questions are also highlighted, along with key avenues for future research, both proof-of-concept and clinical.
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Published date: August 2013
Keywords:
attention, cognition, cognitive flexibility, emotional memory, inhibition, Intra-Dimensional / Extra-Dimensional, Intra-Dimensional Extra-Dimensional, locus coeruleus, modulation, Noradrenaline, norepinephrine, translational, working memory
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Local EPrints ID: 493036
URI: http://eprints.soton.ac.uk/id/eprint/493036
ISSN: 0269-8811
PURE UUID: 580af8cf-38ed-402c-9c66-b947da98c064
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Date deposited: 21 Aug 2024 17:24
Last modified: 22 Aug 2024 02:01
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Author:
Samuel R. Chamberlain
Author:
Trevor W. Robbins
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