Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
421-422
Chamberlain, Samuel R.
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Menzies, Lara
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Hampshire, Adam
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Suckling, John
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Fineberg, Naomi A.
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Del Campo, Natalia
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Aitken, Mike
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Craig, Kevin
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Owen, Adrian M.
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Bullmore, Edward T.
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Robbins, Trevor W.
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Sahakian, Barbara J.
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18 July 2008
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Menzies, Lara
06e7a774-9230-4e28-8862-df8d35f1b624
Hampshire, Adam
08af1acb-f59f-4f42-a1ca-99fd2fb66da2
Suckling, John
3d646fee-f5ed-4d7d-8403-5c4ad7c65504
Fineberg, Naomi A.
157dcac1-9fb2-4197-81f3-0167e1224f05
Del Campo, Natalia
16cfa0d6-12bd-41d1-8ae7-32e6eddc3f60
Aitken, Mike
e4eb587c-82cb-4396-8d2b-eb5d68e19870
Craig, Kevin
e3720ecf-8a3a-481b-9f46-18b7c57b83e4
Owen, Adrian M.
3f478b09-9ee9-41c7-8027-f72441cd6525
Bullmore, Edward T.
6e0f28a8-a70c-4391-a4f4-1172cdb6fd6b
Robbins, Trevor W.
20dd57dd-dbf3-4aaa-b7ba-bb4387ffcbc7
Sahakian, Barbara J.
e689cd5c-b84f-4503-86ca-7526cf340121
Chamberlain, Samuel R., Menzies, Lara, Hampshire, Adam, Suckling, John, Fineberg, Naomi A., Del Campo, Natalia, Aitken, Mike, Craig, Kevin, Owen, Adrian M., Bullmore, Edward T., Robbins, Trevor W. and Sahakian, Barbara J.
(2008)
Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.
Science, 321 (5887), .
(doi:10.1126/science.1154433).
Abstract
Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder.
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Published date: 18 July 2008
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Local EPrints ID: 493119
URI: http://eprints.soton.ac.uk/id/eprint/493119
ISSN: 0036-8075
PURE UUID: a11943fb-6487-47ee-873e-e32569ed89ed
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Date deposited: 23 Aug 2024 16:42
Last modified: 24 Aug 2024 02:00
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Contributors
Author:
Samuel R. Chamberlain
Author:
Lara Menzies
Author:
Adam Hampshire
Author:
John Suckling
Author:
Naomi A. Fineberg
Author:
Natalia Del Campo
Author:
Mike Aitken
Author:
Kevin Craig
Author:
Adrian M. Owen
Author:
Edward T. Bullmore
Author:
Trevor W. Robbins
Author:
Barbara J. Sahakian
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