Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma
Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma
Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.
9-18
Clements, Hollie A
07f95adb-e439-441b-a647-9473464ce2f2
Underwood, Tim J.
8e81bf60-edd2-4b0e-8324-3068c95ea1c6
Petty, Russell
79642f9f-bce2-412f-b60e-47b44fefa604
31 January 2024
Clements, Hollie A
07f95adb-e439-441b-a647-9473464ce2f2
Underwood, Tim J.
8e81bf60-edd2-4b0e-8324-3068c95ea1c6
Petty, Russell
79642f9f-bce2-412f-b60e-47b44fefa604
Clements, Hollie A, Underwood, Tim J. and Petty, Russell
(2024)
Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma.
British Journal of Cancer, 130 (1), .
(doi:10.1038/s41416-023-02458-w).
Abstract
Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.
Text
s41416-023-02458-w
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Accepted/In Press date: 28 September 2023
e-pub ahead of print date: 28 October 2023
Published date: 31 January 2024
Identifiers
Local EPrints ID: 493239
URI: http://eprints.soton.ac.uk/id/eprint/493239
ISSN: 0007-0920
PURE UUID: 212db016-c42d-4216-9e5d-58ae9e4dcb94
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Date deposited: 28 Aug 2024 17:04
Last modified: 29 Aug 2024 01:38
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Author:
Hollie A Clements
Author:
Russell Petty
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