Enantioselective dihydroxylation of perfluoroalkyl-substituted alkenes
Enantioselective dihydroxylation of perfluoroalkyl-substituted alkenes
This contribution gives an overview of the literature regarding the Sharpless Asymmetric Dihydroxylation of alkenes which contain a perfluoroalkyl (RF = CnF2n+1) or a perfluoroalkylidene (R(CF2)n) substituent (hereafter termed “fluorinated alkenes”). Modifications required for these unreactive substrates towards OsO4-mediated dihydroxylation are highlighted, as well as a comparison of enantioselectivities with the corresponding nonfluorinated alkenes.
ligand class, main-group elements, medicinal chemistry, osmium-catalyzed dihydroxylation, facial selectivity, olefins, terminal oxidant, transition-metals, multiple bonds, sharpless asymmetric dihydroxylation
51-54
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
2007
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Linclau, Bruno
(2007)
Enantioselective dihydroxylation of perfluoroalkyl-substituted alkenes.
Chimica Oggi/Chemistry Today, 25 (3), .
Abstract
This contribution gives an overview of the literature regarding the Sharpless Asymmetric Dihydroxylation of alkenes which contain a perfluoroalkyl (RF = CnF2n+1) or a perfluoroalkylidene (R(CF2)n) substituent (hereafter termed “fluorinated alkenes”). Modifications required for these unreactive substrates towards OsO4-mediated dihydroxylation are highlighted, as well as a comparison of enantioselectivities with the corresponding nonfluorinated alkenes.
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Published date: 2007
Additional Information:
Supplement: Focus On Fluorine Chemistry.
Keywords:
ligand class, main-group elements, medicinal chemistry, osmium-catalyzed dihydroxylation, facial selectivity, olefins, terminal oxidant, transition-metals, multiple bonds, sharpless asymmetric dihydroxylation
Identifiers
Local EPrints ID: 49330
URI: http://eprints.soton.ac.uk/id/eprint/49330
ISSN: 0392-839X
PURE UUID: 641afea1-add9-4d23-b23b-8bf566891bec
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Date deposited: 30 Oct 2007
Last modified: 12 Dec 2021 03:11
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