Multimorbidity and risk of falls, fractures, and joint replacements over two decades: findings from the Hertfordshire Cohort Study
Multimorbidity and risk of falls, fractures, and joint replacements over two decades: findings from the Hertfordshire Cohort Study
Aim: to examine the relationship between level of morbidity burden and long-term risk of fractures, falls, and joint replacements in the community-dwelling participants of the Hertfordshire Cohort Study.
Methods: data were analyzed from 2997 individuals (age 59–73 at baseline). Outcomes (fractures, falls, and lower limb joint replacements) were identified using ICD-10 and OPCS-4 codes from Hospital Episode Statistics data, available from baseline (1998–2004) until December 2018. Number of systems medicated (marker of morbidity level) in relation to risk of outcomes was examined using sex-stratified Cox regression.
Results: among both men and women, a greater number of systems medicated was related to increased risk of falls (P < 0.001) and lower limb joint replacements (P < 0.003). More systems medicated was only related to increased risk of fracture among women (P-values for trend of <0.001 among women and 0.186 among men).
Conclusions: higher morbidity was associated with increased risk of adverse health outcomes related to poor musculoskeletal health, but these relationships varied according to the musculoskeletal outcome studied. Intervention strategies to reduce multimorbidity among middle-aged and older people may hence reduce the burden of musculoskeletal aging.
fracture, joint replacement, multimorbidity, osteoarthritis, osteoporosis
Westbury, Leo D.
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Pearse, Camille
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Rambukwella, Roshan
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Ward, Kate A.
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Cooper, Cyrus
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Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Westbury, Leo D.
08fbb4e9-305c-4724-bd0c-b963a5054229
Pearse, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Rambukwella, Roshan
6d02df52-faae-4549-a798-c0211eafe905
Ward, Kate A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Westbury, Leo D., Pearse, Camille, Rambukwella, Roshan, Ward, Kate A., Cooper, Cyrus and Dennison, Elaine M.
(2024)
Multimorbidity and risk of falls, fractures, and joint replacements over two decades: findings from the Hertfordshire Cohort Study.
Geriatrics and Gerontology International.
(doi:10.1111/ggi.14956).
Abstract
Aim: to examine the relationship between level of morbidity burden and long-term risk of fractures, falls, and joint replacements in the community-dwelling participants of the Hertfordshire Cohort Study.
Methods: data were analyzed from 2997 individuals (age 59–73 at baseline). Outcomes (fractures, falls, and lower limb joint replacements) were identified using ICD-10 and OPCS-4 codes from Hospital Episode Statistics data, available from baseline (1998–2004) until December 2018. Number of systems medicated (marker of morbidity level) in relation to risk of outcomes was examined using sex-stratified Cox regression.
Results: among both men and women, a greater number of systems medicated was related to increased risk of falls (P < 0.001) and lower limb joint replacements (P < 0.003). More systems medicated was only related to increased risk of fracture among women (P-values for trend of <0.001 among women and 0.186 among men).
Conclusions: higher morbidity was associated with increased risk of adverse health outcomes related to poor musculoskeletal health, but these relationships varied according to the musculoskeletal outcome studied. Intervention strategies to reduce multimorbidity among middle-aged and older people may hence reduce the burden of musculoskeletal aging.
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Geriatrics Gerontology Int - 2024 - Westbury - Multimorbidity and risk of falls fractures and joint replacements over two
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Accepted/In Press date: 23 July 2024
e-pub ahead of print date: 8 August 2024
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For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) license to any Author Accepted Manuscript version arising from this submission.
Keywords:
fracture, joint replacement, multimorbidity, osteoarthritis, osteoporosis
Identifiers
Local EPrints ID: 493484
URI: http://eprints.soton.ac.uk/id/eprint/493484
ISSN: 1444-1586
PURE UUID: cdfd859f-7335-47c4-a920-8661cc7d852c
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Date deposited: 03 Sep 2024 17:06
Last modified: 04 Sep 2024 01:48
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Author:
Leo D. Westbury
Author:
Camille Pearse
Author:
Roshan Rambukwella
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