Pathogenesis of post-tuberculosis lung disease: defining knowledge gaps and research priorities at the 2nd International Post-Tuberculosis Symposium
Pathogenesis of post-tuberculosis lung disease: defining knowledge gaps and research priorities at the 2nd International Post-Tuberculosis Symposium
Post-tuberculosis (TB) lung disease (PTLD) is increasingly recognized as a major contributor to the global burden of chronic lung disease, with recent estimates indicating that over half of TB survivors have impaired lung function after successful completion of TB treatment. However, the pathologic mechanisms that contribute to PTLD are not well understood, thus limiting the development of therapeutic interventions to improve long-term outcomes after TB. This report summarizes the work of the "Pathogenesis and Risk Factors Committee" for the Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa in April 2023. The committee first identified six areas with high translational potential: (1) tissue matrix destruction, including the role of matrix metalloproteinase dysregulation and neutrophil activity, (2) fibroblasts and profibrotic activity, (3) granuloma fate and cell death pathways, (4) mycobacterial factors including pathogen burden, (5) animal models, and (6) the impact of key clinical risk factors including HIV, diabetes, smoking, malnutrition, and alcohol. We share here the key findings from a literature review of those areas, highlighting knowledge gaps and areas where further research is needed.
Auld, Sara C.
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Barczak, Amy K.
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Bishai, William
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Coussens, Anna K.
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Dewi, Intan M.W.
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Mitini-Nkhoma, Steven C.
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Muefong, Caleb
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Naidoo, Threnesan
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Pooran, Anil
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Stek, Cari
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Steyn, Adrie J.C.
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Tezera, Liku
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Walker, Naomi F.
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Auld, Sara C.
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Barczak, Amy K.
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Bishai, William
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Coussens, Anna K.
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Dewi, Intan M.W.
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Mitini-Nkhoma, Steven C.
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Muefong, Caleb
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Naidoo, Threnesan
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Pooran, Anil
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Stek, Cari
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Steyn, Adrie J.C.
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Tezera, Liku
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Walker, Naomi F.
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Auld, Sara C., Barczak, Amy K., Bishai, William, Coussens, Anna K., Dewi, Intan M.W., Mitini-Nkhoma, Steven C., Muefong, Caleb, Naidoo, Threnesan, Pooran, Anil, Stek, Cari, Steyn, Adrie J.C., Tezera, Liku and Walker, Naomi F.
(2024)
Pathogenesis of post-tuberculosis lung disease: defining knowledge gaps and research priorities at the 2nd International Post-Tuberculosis Symposium.
American Journal of Respiratory and Critical Care Medicine.
(doi:10.1164/rccm.202402-0374SO).
Abstract
Post-tuberculosis (TB) lung disease (PTLD) is increasingly recognized as a major contributor to the global burden of chronic lung disease, with recent estimates indicating that over half of TB survivors have impaired lung function after successful completion of TB treatment. However, the pathologic mechanisms that contribute to PTLD are not well understood, thus limiting the development of therapeutic interventions to improve long-term outcomes after TB. This report summarizes the work of the "Pathogenesis and Risk Factors Committee" for the Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa in April 2023. The committee first identified six areas with high translational potential: (1) tissue matrix destruction, including the role of matrix metalloproteinase dysregulation and neutrophil activity, (2) fibroblasts and profibrotic activity, (3) granuloma fate and cell death pathways, (4) mycobacterial factors including pathogen burden, (5) animal models, and (6) the impact of key clinical risk factors including HIV, diabetes, smoking, malnutrition, and alcohol. We share here the key findings from a literature review of those areas, highlighting knowledge gaps and areas where further research is needed.
Text
Pathogenesis Post-TB Lung Disease (Stellenbosch Review) AJRCCM 2024
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Restricted to Repository staff only until 14 August 2025.
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Accepted/In Press date: 13 August 2024
e-pub ahead of print date: 14 August 2024
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Local EPrints ID: 493787
URI: http://eprints.soton.ac.uk/id/eprint/493787
ISSN: 1073-449X
PURE UUID: 4e4746dd-6867-4b14-9992-32bf2666e40d
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Date deposited: 12 Sep 2024 16:55
Last modified: 13 Sep 2024 01:46
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Contributors
Author:
Sara C. Auld
Author:
Amy K. Barczak
Author:
William Bishai
Author:
Anna K. Coussens
Author:
Intan M.W. Dewi
Author:
Steven C. Mitini-Nkhoma
Author:
Caleb Muefong
Author:
Threnesan Naidoo
Author:
Anil Pooran
Author:
Cari Stek
Author:
Adrie J.C. Steyn
Author:
Naomi F. Walker
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