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Nondestructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation

Müller, Bert, Thurner, Philipp, Beckmann, Felix, Weitkamp, Timm, Rau, Christoph, Bernhardt, Ricardo, Karamuk, Erdal, Eckert, Ludwig, Brandt, J., Buchloh, Stefan, Wintermantel, Erich, Scharnweber, Dieter and Worch, Hartmut, (2002) Nondestructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation Bonse, Ulrich (ed.) In Developments in X-Ray Tomography III. vol. 4503, International Society for Optical Engineering. 11 pp, pp. 178-188. (doi:10.1117/12.452843).

Record type: Conference or Workshop Item (Paper)


Microtomography based on synchrotron radiation sources is a unique technique for the 3D characterization of different materials with a spatial resolution down to about 1 micrometers . The interface between implant materials (metals, ceramics and polymers) and biological matter is nondestructively accessible, i.e. without preparation artifacts. Since the materials exhibit different x-ray absorption, it can become impossible to visualize implant material and tissue, simultaneously. Here, we show that coating of polymer implants, which are invisible in bone tissue, does not only improve the interfacial properties but also allows the imaging of the interface in detail. Titanium implants, on the other hand, absorb the x-rays stronger than bone tissue. The difference, however, is small enough to quantify the bone formation near interface. Another advantage of microtomography with respect to classical histology is the capability to examine samples in a hydrated state. We demonstrate that ceramic hollow spheres can be imaged before sintering and fibroblasts marked by OsO4 are visible on polymer textiles. Consequently, scaffolds of different materials designed for tissue engineering and implant coatings can be optimized on the basis of the tomograms.

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Published date: 2002
Venue - Dates: Proceedings of SPIE, 2002-01-01


Local EPrints ID: 49388
PURE UUID: 24f798d5-787d-4d0a-b39b-c9e179ca5ba8

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Date deposited: 06 Nov 2007
Last modified: 17 Jul 2017 14:56

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Author: Bert Müller
Author: Philipp Thurner
Author: Felix Beckmann
Author: Timm Weitkamp
Author: Christoph Rau
Author: Ricardo Bernhardt
Author: Erdal Karamuk
Author: Ludwig Eckert
Author: J. Brandt
Author: Stefan Buchloh
Author: Erich Wintermantel
Author: Dieter Scharnweber
Author: Hartmut Worch
Editor: Ulrich Bonse

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