P454 Body composition and peripheral muscle function in people with cystic fibrosis established on elexacaftor/tezacaftor/ivacaftor
P454 Body composition and peripheral muscle function in people with cystic fibrosis established on elexacaftor/tezacaftor/ivacaftor
Peripheral muscle dysfunction is common amongst people with cystic fibrosis (CF) – the cause of which is multifactorial. Increasing numbers of people with CF are also overweight and obese, with early evidence suggesting those on the highly effective modulator Elexacaftor/Ivacaftor/Tezacaftor (ETI) to be particularly affected. This increase is associated with elevated fat mass, rather than fat-free mass, which has further detrimental effects on peripheral muscle function. We aimed to comprehensively characterise the body composition and peripheral muscle function (strength, power, endurance and fatigability) in a cohort of people with CF who were stable on ETI compared to healthy controls recruited from Portsmouth and its locality.
S206
Clayton, Lauren J.
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Shepherd, Anthony I.
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Corbett, Jo
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Gruet, Mathieu
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Conett, Gary
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Allenby, Mark
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Legg, Julian
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Daniels, Thomas
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Urquhart, Don S.
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Saynor, Zoe
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Clayton, Lauren J.
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Shepherd, Anthony I.
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Corbett, Jo
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Gruet, Mathieu
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Conett, Gary
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Allenby, Mark
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Legg, Julian
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Daniels, Thomas
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Urquhart, Don S.
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Saynor, Zoe
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Clayton, Lauren J., Shepherd, Anthony I., Corbett, Jo, Gruet, Mathieu, Conett, Gary, Allenby, Mark, Legg, Julian, Daniels, Thomas, Urquhart, Don S. and Saynor, Zoe
(2024)
P454 Body composition and peripheral muscle function in people with cystic fibrosis established on elexacaftor/tezacaftor/ivacaftor.
Journal of Cystic Fibrosis, 23, .
Record type:
Meeting abstract
Abstract
Peripheral muscle dysfunction is common amongst people with cystic fibrosis (CF) – the cause of which is multifactorial. Increasing numbers of people with CF are also overweight and obese, with early evidence suggesting those on the highly effective modulator Elexacaftor/Ivacaftor/Tezacaftor (ETI) to be particularly affected. This increase is associated with elevated fat mass, rather than fat-free mass, which has further detrimental effects on peripheral muscle function. We aimed to comprehensively characterise the body composition and peripheral muscle function (strength, power, endurance and fatigability) in a cohort of people with CF who were stable on ETI compared to healthy controls recruited from Portsmouth and its locality.
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e-pub ahead of print date: 1 June 2024
Identifiers
Local EPrints ID: 493881
URI: http://eprints.soton.ac.uk/id/eprint/493881
ISSN: 1569-1993
PURE UUID: 19f8f081-78cf-485e-8bdb-63b129cdcca6
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Date deposited: 16 Sep 2024 16:50
Last modified: 17 Sep 2024 02:09
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Contributors
Author:
Lauren J. Clayton
Author:
Anthony I. Shepherd
Author:
Jo Corbett
Author:
Mathieu Gruet
Author:
Gary Conett
Author:
Mark Allenby
Author:
Julian Legg
Author:
Thomas Daniels
Author:
Don S. Urquhart
Author:
Zoe Saynor
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