The effect of a novel digital physical activity intervention on health-related quality of life in people with CKD: a multicenter randomized controlled trial (Kidney BEAM) SA-OR18

Greenwood, Sharlene A., Young, Hannah M. and Castle, Ellen M. , Kidney Beam (2023) The effect of a novel digital physical activity intervention on health-related quality of life in people with CKD: a multicenter randomized controlled trial (Kidney BEAM) SA-OR18. Journal of the American Society of Nephrology, 34 (11S), 64, [SA-OR18]. (doi:10.1681/ASN.20233411S164b).

Abstract

Background: remote digital health interventions (DHI) to enhance PA (PA) provide a potential solution to improve health related quality of life (HRQoL) for people with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the effect of a 12-week PA DHI on HRQoL.

Methods: 340 participants with CKD from 11 UK Kidney units were recruited and randomized (1:1) to Kidney BEAM PA DHI (www.beamfeelgood.com) or a waitlist control. The primary outcome was a powered 3-point difference in the Kidney Disease Quality of Life SF 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12-weeks. Secondary outcomes included KDQoL-SF1.3 Physical Component Summary and sub-scales; physical function (sit-to-stand 60, STS60); patient activation (Patient Activation Measure 13, PAM13); anxiety/depression (Patient Health Questionnaire, PHQ4); and fatigue (Chalder Fatigue Scale, CFS). Outcomes were analysed by intention-to-treat approach utilising an analysis of covariance model.

Results: 340 participants were included in the intention-to treat analyses. At 12-weeks there was a significant mean difference between Kidney BEAM and waitlist control in KDQoL MCS score of 3.1 {95% confidence interval (CI): 1.8 to 4.4} arbitrary units (p<0.001). KDQoL burden of kidney disease, energy/fatigue, and social function sub-scales (p=0.049, p=<0.001, and p=0.013, respectively) all improved in favour of the intervention. Physical function also improved (STS60 mean between-group difference: 4 {95% CI: 3 to 5} repetitions (p<0.001) and patient activation was enhanced (PAM13 mean between-group difference: 6.9 {95% CI: 4.9 to 8.8} points (p<0.001)). Fatigue and anxiety/depression were unchanged (p=0.33 and p=0.08, respectively).

Conclusions: these results demonstrate that the Kidney BEAM DHI is an effective innovation to improve mental HRQoL in people with CKD. This is the first large randomised controlled trial of an effective, and deliverable, PA DHI for people with CKD.

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Contributors

Author: Zoe L. Saynor

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