Analysis of oxygen uptake efficiency parameters in young people with cystic fibrosis

Abstract

Purpose: this study characterised oxygen uptake efficiency (OUE) in children with mild-to-moderate cystic fibrosis (CF). Specifically, it investigated 1) the utility of OUE parameters as potential submaximal surrogates of peak oxygen uptake (VO_2peak), and 2) the relationship between OUE and disease severity.

Methods: cardiopulmonary exercise test (CPET) data were collated from 72 children (36 CF, 36 age- and sex-matched controls [CON]), with OUE assessed as its highest 90-s average (plateau; OUEP), the gas exchange threshold (OUE_GET) and respiratory compensation point (OUE_RCP). Pearson’s correlation coefficients, independent t-tests and factorial ANOVAs assessed differences between groups and the use of OUE measures as surrogates for VO_2peak.

Results: a significant (p < 0.05) reduction in allometrically scaled VO_2peak and all OUE parameters was found in CF. Significant (p < 0.05) correlations between measurements of OUE and allometrically scaled VO_2peak, were observed in CF (r = 0.49 – 0.52) and CON (r = 0.46 – 0.52). Furthermore, measures of OUE were significantly (p < 0.05) correlated with pulmonary function (FEV_1%predicted) in CF (r = 0.38 – 0.46), but not CON (r = -0.20 – 0.14). OUEP was able to differentiate between different aerobic fitness tertiles in CON but not CF.

Conclusions: OUE parameters were reduced in CF, but were not a suitable surrogate for VO_2peak. Clinical teams should, where possible, continue to utilise maximal CPET parameters to measure aerobic fitness in children and adolescents with CF. Future research should assess the prognostic utility of OUEP as it does appear sensitive to disease status and severity.

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Identifiers

ORCID for Zoe L. Saynor: orcid.org/0000-0003-0674-8477

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