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Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM: a single-blind crossover trial

Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM: a single-blind crossover trial
Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM: a single-blind crossover trial
High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM). Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults with T2DM [glycated haemoglobin (HbA1c): 61.1 ± 14.1 mmol mol−1; aged 64.2 ± 9.4 years; four female] completed a single-blind, randomised, sham-controlled, cross-over study for 10 nights, sleeping when exposed to hypoxia (fractional inspired O2 [
accelerometery, exercise mimetic, hypoxia, type 2 diabetes, weight loss
0022-3751
Shepherd, Anthony I.
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James, Thomas J.
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Gould, Alex A.M.
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Mayes, Harry
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Neal, Rebecca
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Shute, Janis
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Tipton, Mike
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Massey, Heather
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Saynor, Zoe L.
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Perissiou, Maria
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Montgomery, Hugh
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Sturgess, Connie
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Makaronidis, Janine
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Murray, Andrew J.
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Grocott, Michael P. W.
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Cummings, Michael
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Young-Min, Steven
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Rennell-Smyth, Janet
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McNarry, Melitta A.
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Mackintosh, Kelly A.
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Dent, Hannah
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Robson, Samuel
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Corbett, Jo
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Shepherd, Anthony I.
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James, Thomas J.
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Gould, Alex A.M.
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Mayes, Harry
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Neal, Rebecca
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Shute, Janis
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Tipton, Mike
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Massey, Heather
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Saynor, Zoe L.
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Perissiou, Maria
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Montgomery, Hugh
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Sturgess, Connie
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Makaronidis, Janine
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Murray, Andrew J.
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Grocott, Michael P. W.
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Cummings, Michael
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Young-Min, Steven
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Rennell-Smyth, Janet
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McNarry, Melitta A.
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Mackintosh, Kelly A.
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Dent, Hannah
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Robson, Samuel
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Corbett, Jo
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Shepherd, Anthony I., James, Thomas J., Gould, Alex A.M., Mayes, Harry, Neal, Rebecca, Shute, Janis, Tipton, Mike, Massey, Heather, Saynor, Zoe L., Perissiou, Maria, Montgomery, Hugh, Sturgess, Connie, Makaronidis, Janine, Murray, Andrew J., Grocott, Michael P. W., Cummings, Michael, Young-Min, Steven, Rennell-Smyth, Janet, McNarry, Melitta A., Mackintosh, Kelly A., Dent, Hannah, Robson, Samuel and Corbett, Jo (2024) Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM: a single-blind crossover trial. The Journal of Physiology. (doi:10.1113/JP285322).

Record type: Article

Abstract

High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM). Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemic control, appetite, gut microbiota and inflammation in adults with T2DM. Thirteen adults with T2DM [glycated haemoglobin (HbA1c): 61.1 ± 14.1 mmol mol−1; aged 64.2 ± 9.4 years; four female] completed a single-blind, randomised, sham-controlled, cross-over study for 10 nights, sleeping when exposed to hypoxia (fractional inspired O2 [

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The Journal of Physiology - 2024 - Shepherd - Impact of nocturnal hypoxia on glycaemic control appetite gut microbiota - Version of Record
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Accepted/In Press date: 22 April 2024
e-pub ahead of print date: 20 May 2024
Keywords: accelerometery, exercise mimetic, hypoxia, type 2 diabetes, weight loss
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Identifiers

Local EPrints ID: 494046
URI: http://eprints.soton.ac.uk/id/eprint/494046
DOI: doi:10.1113/JP285322
ISSN: 0022-3751
PURE UUID: 91505f64-87cd-4998-8c8c-acfc82a31a98
ORCID for Zoe L. Saynor: ORCID iD orcid.org/0000-0003-0674-8477
ORCID for Michael P. W. Grocott: ORCID iD orcid.org/0000-0002-9484-7581

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Date deposited: 20 Sep 2024 16:38
Last modified: 21 Sep 2024 02:14

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Contributors

Author: Anthony I. Shepherd
Author: Thomas J. James
Author: Alex A.M. Gould
Author: Harry Mayes
Author: Rebecca Neal
Author: Janis Shute
Author: Mike Tipton
Author: Heather Massey
Author: Zoe L. Saynor ORCID iD
Author: Maria Perissiou
Author: Hugh Montgomery
Author: Connie Sturgess
Author: Janine Makaronidis
Author: Andrew J. Murray
Author: Michael P. W. Grocott ORCID iD
Author: Michael Cummings
Author: Steven Young-Min
Author: Janet Rennell-Smyth
Author: Melitta A. McNarry
Author: Kelly A. Mackintosh
Author: Hannah Dent
Author: Samuel Robson
Author: Jo Corbett

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