WS16.2 the reliability of maximal cardiopulmonary exercise testing for young cystic fibrosis patients

Williams, Craig Anthony, Saynor, Zoe L., Barker, Alan R. and Oades, Patrick John (2012) WS16.2 the reliability of maximal cardiopulmonary exercise testing for young cystic fibrosis patients. Journal of Cystic Fibrosis, 11 (S1), S35. (doi:10.1016/S1569-1993(12)60110-6).

Abstract

Background: Maximal cardiopulmonary exercise testing (CPET) is the most precise method for evaluating physical function of patients with mild-to-moderate cystic fibrosis (CF). This study sought to establish the between trial variation of CPET parameters across three different time points. Methods: Fourteen 7−18 year olds (10 male) completed an incremental ramp cycle test to exhaustion. Peak oxygen uptake (V˙ O2peak), power output (Wpeak), heart rate (HRpeak ) and end-exercise oxygen saturation (SaO2%) and breathlessness (RPD) were determined. Following 15-min recovery supramaximal exercise to exhaustion was performed at a work rate (WR) equal to 110% ramp Wpeak (T1). Testing was repeated 48 h (T2) and 4−6 weeks later (T3). Intra-class retest correlations, change in the mean score [V˙ O2peak] and the typical error for all measurements assessed reliability. Results: Intra-class correlations ranged from r = 0.57–0.99 and were highest for WR. No significant differences in mean (SD) V˙ O2peak were found between T1-T2; 1.91 (0.80) and 1.93 (0.66) L×min−1, p = 0.79; T2-T3 1.81 (0.48) and 1.68 (0.50) L×min−1, n = 13, p = 0.20 and T1-T3 1.77 (0.63) and 1.68 (0.50) L×min−1, n = 13, p = 0.25, respectively. The highest typical error for HRpeak (T1-T2), WR (T2-T3), RPD (T1-T2), SaO2% (T2-T3), and V˙ O2peak (T1-T2) were 12, 9.3, 1.4, 1.3 and 0.3%, respectively. Conclusion: CPET derived variables especially V˙ O2peak are highly reproducible between 1 and 42 days. Clinicians can have confidence in precisely reproducing the effect of exercise/pharmacological interventions or CF disease on parameters obtained during CPET. Acknowledgments: Supported by the Peninsula NIHR Research Facility.

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Contributors

Author: Zoe L. Saynor

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