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From O’Shaughnessy to opportunity: innovating hepatology trials in the UK

From O’Shaughnessy to opportunity: innovating hepatology trials in the UK
From O’Shaughnessy to opportunity: innovating hepatology trials in the UK
Developing new treatments that improve outcomes for patients with decompensated cirrhosis remains an unmet area of clinical need. The UK has a rich history of being on the forefront of clinical trials for this patient group. However, there have been challenges in achieving this goal in the past decade, with several negative studies as well as trials struggling to achieve recruitment. This has been further exacerbated by the changed clinical landscape following the COVID-19 pandemic. In response to this, the O’Shaughnessy report was commissioned to identify potential opportunities to improve clinical trial performance in the UK. In this review article, we identify critical areas for the UK hepatology community to collaborate and develop sustainable partnerships for clinical trial delivery which will ensure that outcomes are representative, inclusive and patient-centred.
Hepatology, RCT, UK, health service research, clinical trials, cirrhosis
2041-4137
395-400
Tavabie, Oliver D.
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Enever, Yvanne
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Green, Daniel
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Crisp, Helen
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Tsochatzis, Emmanouil
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Gander, Amir
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Mansour, Dina
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Hebditch, Vanessa
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Adams, Julie
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Ashbourn, Adam
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Mysko, Christopher
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Allen, Richard
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Kent, Laura
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Maurice, James B.
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Srivastava, Ankur
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Chauhan, Abhishek
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Johnston, Tom
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Ruane, Janet
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Varni, Rebecca
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Fletcher, Caroline
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Sieberhagen, Cyril
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Hay, Gordon
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Bretland, Giovanna
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Corrigan, Maggie
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Ferraro, Francesco
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McMahon, Riley
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Burge, Trudie
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Ferguson, Harry
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Jennings, Louise
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Hogan, Brian
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Cook, Andrew
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Jalan, Rajiv
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Mehta, Gautam
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et al.
Tavabie, Oliver D.
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Enever, Yvanne
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Green, Daniel
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Crisp, Helen
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Tsochatzis, Emmanouil
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Gander, Amir
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Mansour, Dina
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Hebditch, Vanessa
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Adams, Julie
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Ashbourn, Adam
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Mysko, Christopher
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Allen, Richard
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Kent, Laura
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Maurice, James B.
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Srivastava, Ankur
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Chauhan, Abhishek
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Johnston, Tom
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Ruane, Janet
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Varni, Rebecca
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Fletcher, Caroline
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Sieberhagen, Cyril
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Hay, Gordon
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Bretland, Giovanna
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Corrigan, Maggie
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Ferraro, Francesco
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McMahon, Riley
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Burge, Trudie
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Ferguson, Harry
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Jennings, Louise
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Hogan, Brian
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Cook, Andrew
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Jalan, Rajiv
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Mehta, Gautam
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Tavabie, Oliver D., Enever, Yvanne and Green, Daniel , et al. (2024) From O’Shaughnessy to opportunity: innovating hepatology trials in the UK. Frontline Gastroenterology, 15 (5), 395-400. (doi:10.1136/flgastro-2024-102710).

Record type: Review

Abstract

Developing new treatments that improve outcomes for patients with decompensated cirrhosis remains an unmet area of clinical need. The UK has a rich history of being on the forefront of clinical trials for this patient group. However, there have been challenges in achieving this goal in the past decade, with several negative studies as well as trials struggling to achieve recruitment. This has been further exacerbated by the changed clinical landscape following the COVID-19 pandemic. In response to this, the O’Shaughnessy report was commissioned to identify potential opportunities to improve clinical trial performance in the UK. In this review article, we identify critical areas for the UK hepatology community to collaborate and develop sustainable partnerships for clinical trial delivery which will ensure that outcomes are representative, inclusive and patient-centred.

Text
O'Shaughnessy_270224 - Accepted Manuscript
Available under License Creative Commons Attribution Non-commercial.
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More information

Accepted/In Press date: 27 June 2024
e-pub ahead of print date: 13 July 2024
Published date: 8 August 2024
Keywords: Hepatology, RCT, UK, health service research, clinical trials, cirrhosis

Identifiers

Local EPrints ID: 494467
URI: http://eprints.soton.ac.uk/id/eprint/494467
DOI: doi:10.1136/flgastro-2024-102710
ISSN: 2041-4137
PURE UUID: aab9aba9-bb13-41a6-bbb2-253fc3ff5644
ORCID for Andrew Cook: ORCID iD orcid.org/0000-0002-6680-439X

Catalogue record

Date deposited: 09 Oct 2024 16:34
Last modified: 11 Oct 2024 01:40

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Contributors

Author: Oliver D. Tavabie
Author: Yvanne Enever
Author: Daniel Green
Author: Helen Crisp
Author: Emmanouil Tsochatzis
Author: Amir Gander
Author: Dina Mansour
Author: Vanessa Hebditch
Author: Julie Adams
Author: Adam Ashbourn
Author: Christopher Mysko
Author: Richard Allen
Author: Laura Kent
Author: James B. Maurice
Author: Ankur Srivastava
Author: Abhishek Chauhan
Author: Tom Johnston
Author: Janet Ruane
Author: Rebecca Varni
Author: Caroline Fletcher
Author: Cyril Sieberhagen
Author: Gordon Hay
Author: Giovanna Bretland
Author: Maggie Corrigan
Author: Francesco Ferraro
Author: Riley McMahon
Author: Trudie Burge
Author: Harry Ferguson
Author: Louise Jennings
Author: Brian Hogan
Author: Andrew Cook ORCID iD
Author: Rajiv Jalan
Author: Gautam Mehta
Corporate Author: et al.

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