Domain general sequence operations contribute to pre-SMA involvement in visuo-spatial processing

Leek, E. Charles, Yuen, Kenneth S.L. and Johnston, Stephen J. (2016) Domain general sequence operations contribute to pre-SMA involvement in visuo-spatial processing. Frontiers in Human Neuroscience, 10, [9]. (doi:10.3389/fnhum.2016.00009).

Abstract

This study used 3T MRI to elucidate the functional role of supplementary motor area (SMA) in relation to visuo-spatial processing. A localizer task contrasting sequential number subtraction and repetitive button pressing was used to functionally delineate non-motor sequence processing in pre-SMA, and activity in SMA-proper associated with motor sequencing. Patterns of BOLD responses in these regions were then contrasted to those from two tasks of visuo-spatial processing. In one task participants performed Mental Rotation (MR) in which recognition memory judgments were made to previously memorized 2D novel patterns across image-plane rotations. The other task involved abstract grid navigation (GN) in which observers computed a series of imagined location shifts in response to directional (arrow) cues around a mental grid. The results showed overlapping activation in pre-SMA for sequential subtraction and both visuo-spatial tasks. These results suggest that visuo-spatial processing is supported by non-motor sequence operations that involve pre-SMA. More broadly, these data further highlight the functional heterogeneity of pre-SMA, and show that its role extends to processes beyond the planning and online control of movement.

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Contributors

Author: E. Charles Leek

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