Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
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Takeuchi, F.
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Akiyama, M.
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Matoba, N.
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Couto Alves, A.D.S.
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
al, et
92ccc94a-7496-4a9a-bc72-d148b181bac3
28 November 2018
Takeuchi, F.
23e7516c-db20-4d63-ae9d-b7f52b776251
Akiyama, M.
da1618d3-5a90-48e6-a9bb-d2e4f8f6e622
Matoba, N.
6ba0b641-ed3d-4660-83d3-74e491166141
Couto Alves, A.D.S.
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
al, et
92ccc94a-7496-4a9a-bc72-d148b181bac3
Takeuchi, F., Akiyama, M., Matoba, N., Couto Alves, A.D.S. and al, et
(2018)
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
Nature Communications, .
(doi:10.1038/s41467-018-07345-0).
Abstract
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
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s41467-018-07345-0
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Accepted/In Press date: 29 October 2018
Published date: 28 November 2018
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Local EPrints ID: 494713
URI: http://eprints.soton.ac.uk/id/eprint/494713
ISSN: 2041-1723
PURE UUID: e3a4c39f-755d-411c-8d2d-4827b07cf61b
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Date deposited: 14 Oct 2024 16:48
Last modified: 19 Oct 2024 02:14
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Author:
F. Takeuchi
Author:
M. Akiyama
Author:
N. Matoba
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A.D.S. Couto Alves
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et al
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