Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
Background:
Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels.
Design and methods:
We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC strata. In each stratum, additional metabolomics association analyses with testosterone levels were conducted separately among cases and controls.
Results:
Overall, women with PCOS showed more adverse metabolite profiles than the controls. Four lipid fractions in different subclasses of very low density lipoprotein (VLDL) were associated with PCOS, after adjusting for WC and correction for multiple testing (P<0.002). In stratified analysis the PCOS women within large WC strata (⩾98 cm) had significantly lower high density lipoprotein (HDL) levels, Apo A1 and albumin values compared with the controls. Testosterone levels were significantly associated with VLDL and serum lipids in PCOS cases with large WC but not in the controls. The higher testosterone levels, adjusted for WC, associated adversely with insulin levels and HOMA IR in cases but not in the controls.
Conclusions:
Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS.
Couto Alves, A.
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Valcarcel, B.
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Mäkinen, V.-P.
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Morin-Papunen, L.
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Sebert, S.
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Kangas, A.J.
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Soininen, P.
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Das, S.
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De Iorio, M.
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Coin, L.
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Ala-Korpela, M.
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Järvelin, M.-R.
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Franks, S.
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26 May 2017
Couto Alves, A.
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Valcarcel, B.
d012f3dc-f190-4379-988c-09dcf0c2a479
Mäkinen, V.-P.
6ea9bbb0-33b9-4161-a63d-e70fa8038eb0
Morin-Papunen, L.
63f001c8-411e-4da5-a259-d4b01232f99c
Sebert, S.
aafd73c5-7a5a-4fc2-8844-1d61b6e8cb6b
Kangas, A.J.
a531ae11-2a85-4f9c-abf1-bd75e38d8f26
Soininen, P.
3dd4fe75-3f87-460d-a353-b60d531cf773
Das, S.
d2b895e0-75f3-48f4-be0c-2a5e651e49d8
De Iorio, M.
8c633792-cc05-4966-a19c-3322c83c5443
Coin, L.
c5d53891-0f8f-46e2-983a-6f50e6fb435b
Ala-Korpela, M.
29cc1135-7255-47a6-b2e2-217efc6681db
Järvelin, M.-R.
4357ab7f-a0ea-46fd-8774-ca11ecd29b74
Franks, S.
06c2f7e6-e52f-479d-beae-dad7f7831ff0
Couto Alves, A., Valcarcel, B., Mäkinen, V.-P., Morin-Papunen, L., Sebert, S., Kangas, A.J., Soininen, P., Das, S., De Iorio, M., Coin, L., Ala-Korpela, M., Järvelin, M.-R. and Franks, S.
(2017)
Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity.
International journal of obesity.
(doi:10.1038/ijo.2017.126).
Abstract
Background:
Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels.
Design and methods:
We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC strata. In each stratum, additional metabolomics association analyses with testosterone levels were conducted separately among cases and controls.
Results:
Overall, women with PCOS showed more adverse metabolite profiles than the controls. Four lipid fractions in different subclasses of very low density lipoprotein (VLDL) were associated with PCOS, after adjusting for WC and correction for multiple testing (P<0.002). In stratified analysis the PCOS women within large WC strata (⩾98 cm) had significantly lower high density lipoprotein (HDL) levels, Apo A1 and albumin values compared with the controls. Testosterone levels were significantly associated with VLDL and serum lipids in PCOS cases with large WC but not in the controls. The higher testosterone levels, adjusted for WC, associated adversely with insulin levels and HOMA IR in cases but not in the controls.
Conclusions:
Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS.
Text
ijo2017126
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Accepted/In Press date: 26 March 2017
Published date: 26 May 2017
Identifiers
Local EPrints ID: 494833
URI: http://eprints.soton.ac.uk/id/eprint/494833
ISSN: 0307-0565
PURE UUID: aa27f786-0dda-4962-b2f7-20e22605ea6d
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Date deposited: 16 Oct 2024 16:44
Last modified: 17 Oct 2024 02:08
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Contributors
Author:
A. Couto Alves
Author:
B. Valcarcel
Author:
V.-P. Mäkinen
Author:
L. Morin-Papunen
Author:
S. Sebert
Author:
A.J. Kangas
Author:
P. Soininen
Author:
S. Das
Author:
M. De Iorio
Author:
L. Coin
Author:
M. Ala-Korpela
Author:
M.-R. Järvelin
Author:
S. Franks
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