RAGE receptor and its soluble isoforms in diabetes mellitus complications
RAGE receptor and its soluble isoforms in diabetes mellitus complications
Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.
Oliveira, Mauren Isfer Anghebem
26078326-8fde-4e88-a0e4-a817868609a9
Souza, Emanuel Maltempi de
85fe89fd-6282-4987-818d-c922db1035a4
Pedrosa, Fábio de Oliveira
7e10e266-7c38-4a46-99cb-34472850dbd2
Réa, Rosângela Roginski
2b87f1db-2740-4ac1-85d1-9da01c5b3e56
Couto Alves, Alexessander
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Picheth, Geraldo
83111b68-458e-49d9-ad5f-6096d4bf50f2
Rego, Fabiane Gomes de Moraes
28dc6fa5-ce01-4186-8490-d6008996b58a
20 April 2013
Oliveira, Mauren Isfer Anghebem
26078326-8fde-4e88-a0e4-a817868609a9
Souza, Emanuel Maltempi de
85fe89fd-6282-4987-818d-c922db1035a4
Pedrosa, Fábio de Oliveira
7e10e266-7c38-4a46-99cb-34472850dbd2
Réa, Rosângela Roginski
2b87f1db-2740-4ac1-85d1-9da01c5b3e56
Couto Alves, Alexessander
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Picheth, Geraldo
83111b68-458e-49d9-ad5f-6096d4bf50f2
Rego, Fabiane Gomes de Moraes
28dc6fa5-ce01-4186-8490-d6008996b58a
Oliveira, Mauren Isfer Anghebem, Souza, Emanuel Maltempi de, Pedrosa, Fábio de Oliveira, Réa, Rosângela Roginski, Couto Alves, Alexessander, Picheth, Geraldo and Rego, Fabiane Gomes de Moraes
(2013)
RAGE receptor and its soluble isoforms in diabetes mellitus complications.
Jornal Brasileiro de Patologia e Medicina Laboratorial.
(doi:10.1590/s1676-24442013000200004).
Abstract
Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.
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Accepted/In Press date: 13 November 2012
Published date: 20 April 2013
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Local EPrints ID: 494929
URI: http://eprints.soton.ac.uk/id/eprint/494929
PURE UUID: 1a9cbc3b-3b87-44d7-9ae7-adb8fb499a74
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Date deposited: 23 Oct 2024 16:51
Last modified: 24 Oct 2024 02:11
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Author:
Mauren Isfer Anghebem Oliveira
Author:
Emanuel Maltempi de Souza
Author:
Fábio de Oliveira Pedrosa
Author:
Rosângela Roginski Réa
Author:
Alexessander Couto Alves
Author:
Geraldo Picheth
Author:
Fabiane Gomes de Moraes Rego
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