Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Demenais, Florence
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Margaritte-Jeannin, Patricia
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Couto Alves, Alexessander
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Barnes, Kathleen C.
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Cookson, William O.C.M.
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Altmüller, Janine
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Ang, Wei
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22 December 2017
Demenais, Florence
624f1028-a62d-4ee5-8059-cce1fdb4cb05
Margaritte-Jeannin, Patricia
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Couto Alves, Alexessander
87b9179e-abde-4ca5-abfc-4b7c5ac8b03b
Barnes, Kathleen C.
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Cookson, William O.C.M.
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Altmüller, Janine
773fa948-4505-436f-8669-e481675140e7
Ang, Wei
fab41904-013a-41f3-af55-3081a2383a85
et al.
(2017)
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Nature Genetics.
(doi:10.1038/s41588-017-0014-7).
Abstract
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
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s41588-017-0014-7 (1)
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Accepted/In Press date: 8 November 2017
Published date: 22 December 2017
Identifiers
Local EPrints ID: 495008
URI: http://eprints.soton.ac.uk/id/eprint/495008
ISSN: 1061-4036
PURE UUID: 8e3325d4-a771-443c-b719-6737ac7127f4
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Date deposited: 25 Oct 2024 16:45
Last modified: 26 Oct 2024 02:12
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Contributors
Author:
Florence Demenais
Author:
Patricia Margaritte-Jeannin
Author:
Alexessander Couto Alves
Author:
Kathleen C. Barnes
Author:
William O.C.M. Cookson
Author:
Janine Altmüller
Author:
Wei Ang
Corporate Author: et al.
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