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Ischemic conditioning in kidney transplantation

Ischemic conditioning in kidney transplantation
Ischemic conditioning in kidney transplantation
Ischemia–reperfusion injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained on reperfusion, which limits the amount of tissue that can be salvaged. Ischemia–reperfusion injury is the predominant insult during kidney transplantation, contributing to graft dysfunction, increased rates of acute rejection, and reduced rejection-free graft survival. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, ischemic preconditioning, and its potential for improving kidney function following transplantation.
Veighey, K
2adbaf5c-141a-44bd-a7eb-faf14e0ca251
MacAllister, R
9f4b26b2-72e1-4ccf-9338-362d6193085b
Veighey, K
2adbaf5c-141a-44bd-a7eb-faf14e0ca251
MacAllister, R
9f4b26b2-72e1-4ccf-9338-362d6193085b

Veighey, K and MacAllister, R (2017) Ischemic conditioning in kidney transplantation. Journal of Cardiovascular Pharmacology and Therapeutics. (doi:10.1177/1074248417702893).

Record type: Article

Abstract

Ischemia–reperfusion injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained on reperfusion, which limits the amount of tissue that can be salvaged. Ischemia–reperfusion injury is the predominant insult during kidney transplantation, contributing to graft dysfunction, increased rates of acute rejection, and reduced rejection-free graft survival. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, ischemic preconditioning, and its potential for improving kidney function following transplantation.

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Published date: 11 April 2017
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Local EPrints ID: 495044
URI: http://eprints.soton.ac.uk/id/eprint/495044
DOI: doi:10.1177/1074248417702893
PURE UUID: 55fc52d6-b752-4700-b74a-428536a7f097
ORCID for K Veighey: ORCID iD orcid.org/0000-0003-4903-1847

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Date deposited: 28 Oct 2024 17:51
Last modified: 29 Oct 2024 02:57

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Author: K Veighey ORCID iD
Author: R MacAllister

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