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A dominant bursting electromyograph pattern in dystonic conditions predicts an early response to pallidal stimulation

Record type: Article

Although chronic pallidal deep brain stimulation (DBS) is effective in the treatment of medically intractable dystonia, there is no way of predicting the variations in clinical outcome, partly due to our limited understanding of the pathophysiological mechanisms underlying this condition. We recorded electromyographic (EMG) activity from the most severely affected muscle groups in seven dystonia patients before and after pallidal DBS. Patient EMG recordings could be classified into two groups: one consisting of patients who at rest demonstrated a dominant low frequency component of activity on power spectral analysis (ranging from 2 to 5 Hz), and one group in which this dominant pattern was absent. Early postoperative improvements (within 2–3 days) were observed in the former group, whereas the latter group benefited more gradually (over several months). Analysis of EMG activity may provide a sensitive means of identifying dystonic patients who are likely to be most responsive to functional neurosurgical intervention.

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Citation

Yianni, John, Wang, Shou Yan, Liu, Xuguang, Bain, Peter G., Nandi, Dipankar, Gregory, Ralph, Joint, Carole, Stein, John F. and Aziz, Tipu Z. (2006) A dominant bursting electromyograph pattern in dystonic conditions predicts an early response to pallidal stimulation Journal of Clinical Neuroscience, 13, (7), pp. 738-746. (doi:10.1016/j.jocn.2005.07.022).

More information

Published date: August 2006
Keywords: dystonia, EMG, pallidum, stimulation
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 49596
URI: http://eprints.soton.ac.uk/id/eprint/49596
ISSN: 0967-5868
PURE UUID: 77353f06-b621-432f-b888-01685a8c2957

Catalogue record

Date deposited: 21 Nov 2007
Last modified: 17 Jul 2017 14:55

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Contributors

Author: John Yianni
Author: Shou Yan Wang
Author: Xuguang Liu
Author: Peter G. Bain
Author: Dipankar Nandi
Author: Ralph Gregory
Author: Carole Joint
Author: John F. Stein
Author: Tipu Z. Aziz

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