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The physiologically modulated electrode potentials at the depth electrode-brain interface in humans

Xie, K., Wang, S., Aziz, T.Z., Stein, J.F. and Liu, X. (2006) The physiologically modulated electrode potentials at the depth electrode-brain interface in humans Neuroscience Letters, 402, (3), pp. 238-243. (doi:10.1016/j.neulet.2006.04.015).

Record type: Article

Abstract

To study the modulated electrical potential specifically related to the electrode–brain interface (EBI) in deep brain stimulation (DBS) under physiological condition, we quantitatively identified the physiologically modulated electrode potentials by decomposing the local field potentials (LFPs) recorded from 11 patients (18 electrodes in four different brain regions) who underwent DBS, and correlated them with simultaneously recorded physiological signals of blood pressure (BP) and respiration. Results showed that electrode potentials were modulated by BP and respiration and could be detected as a specific component of the compound LFP signals with a mean (±S.D.) amplitude of 6.9 ± 1.7 ?V. The detection rate and amplitude of the modulated electrode potentials were independent from brain regions and neurological disorders. The current approach can be used to study the changes in properties of the EBI under physiological condition and to investigate the effects of the EBI on the ‘crossing’ current of either the neural signals to be recorded or the electrical pulses for neurostimulation.

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More information

Published date: 24 July 2006
Keywords: deep brain stimulation, electrode potentials, local field potentials, brain pulsation, electrode–brain interface
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 49597
URI: http://eprints.soton.ac.uk/id/eprint/49597
ISSN: 0304-3940
PURE UUID: 03f86821-ef49-4a6a-8d23-69948c5f74ed

Catalogue record

Date deposited: 21 Nov 2007
Last modified: 17 Jul 2017 14:55

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Contributors

Author: K. Xie
Author: S. Wang
Author: T.Z. Aziz
Author: J.F. Stein
Author: X. Liu

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