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Deep brain stimulation can regulate arterial blood pressure in awake humans

Deep brain stimulation can regulate arterial blood pressure in awake humans
Deep brain stimulation can regulate arterial blood pressure in awake humans
The periaqueductal grey matter is known to play a role in cardiovascular control in animals. Cardiovascular responses to electrical stimulation of the periventricular/periaqueductal grey matter were measured in 15 awake human study participants following implantation of deep brain stimulating electrodes for treatment of chronic pain. We found that stimulation of the ventral periventricular/periaqueductal grey matter caused a mean reduction in systolic blood pressure of 14.2+/-3.6 mmHg in seven patients and stimulation of the dorsal periventricular/periaqueductal grey matter caused a mean increase of 16.7+/-5.9 mmHg in six patients. A comparison between ventral and dorsal electrodes demonstrated significant differences (P<0.05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP/dt but not in the time interval between each R wave on the electrocardiogram.
1741-1745
Green, A.L.
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Wang, S.
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Owen, S.L.F.
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Xie, K.
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Liu, Z.
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Paterson, D.J.
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Stein, J.F.
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Bain, P.G.
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Aziz, T.Z.
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Green, A.L.
d7df7b1a-1a56-495a-b93e-6d8211279e29
Wang, S.
8bce5bdb-420c-4b22-b009-8f4ce1febaa8
Owen, S.L.F.
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Xie, K.
88f73105-c5d5-400c-b96f-d7a4168bb333
Liu, Z.
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Paterson, D.J.
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Stein, J.F.
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Bain, P.G.
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Aziz, T.Z.
728d8821-5fa0-407f-a09f-5a52038ad170

Green, A.L., Wang, S., Owen, S.L.F., Xie, K., Liu, Z., Paterson, D.J., Stein, J.F., Bain, P.G. and Aziz, T.Z. (2005) Deep brain stimulation can regulate arterial blood pressure in awake humans. NeuroReport, 16 (16), 1741-1745.

Record type: Article

Abstract

The periaqueductal grey matter is known to play a role in cardiovascular control in animals. Cardiovascular responses to electrical stimulation of the periventricular/periaqueductal grey matter were measured in 15 awake human study participants following implantation of deep brain stimulating electrodes for treatment of chronic pain. We found that stimulation of the ventral periventricular/periaqueductal grey matter caused a mean reduction in systolic blood pressure of 14.2+/-3.6 mmHg in seven patients and stimulation of the dorsal periventricular/periaqueductal grey matter caused a mean increase of 16.7+/-5.9 mmHg in six patients. A comparison between ventral and dorsal electrodes demonstrated significant differences (P<0.05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP/dt but not in the time interval between each R wave on the electrocardiogram.

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Published date: 7 November 2005
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 49599
URI: http://eprints.soton.ac.uk/id/eprint/49599
PURE UUID: 3bfe5e9e-956b-4515-876d-56b6e173dd79

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Date deposited: 21 Nov 2007
Last modified: 04 Oct 2022 16:53

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Contributors

Author: A.L. Green
Author: S. Wang
Author: S.L.F. Owen
Author: K. Xie
Author: Z. Liu
Author: D.J. Paterson
Author: J.F. Stein
Author: P.G. Bain
Author: T.Z. Aziz

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