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Quantifying drug-induced dyskinesias in the arms using two different spiral-drawing tasks

Quantifying drug-induced dyskinesias in the arms using two different spiral-drawing tasks
Quantifying drug-induced dyskinesias in the arms using two different spiral-drawing tasks
In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are designed to, respectively, represent the continuous and discrete arm motions, and the size of the spiral is decided so that both the distal and proximal arm joints are involved. Fifteen PD patients, average disease duration 14.4+/-7.4 years, were assessed 30 min after a levodopa challenge whilst performing circular and square spiral-drawing tasks. The velocity of drawing movements was computed and the amplitude of the involuntary dyskinetic movements was measured as the standard deviation of the drawing velocity (SD-DV). The mean amplitude of dyskinetic movements was compared between arms and tasks and was correlated with clinical measures including the Bain dyskinesia scale and the total unified Parkinson's disease rating scale (UPDRS) score. The results showed that there was no statistically significant difference in the amplitude of dyskinesias either between the arms or between the continuous (circular) and discrete (square) spiral drawings in this group of PD patients, but interestingly the interaction between arm and drawing pattern was significant. Significant correlations were found between the magnitude of dyskinesia measured from the spiral-drawing tasks and both the 'on' or 'off' UPDRS and also the Bain dyskinesia scale. We conclude that the drawing tasks may be used to provide an objective method of quantifying the severity of drug-induced dyskinesias in the arm in PD patients.
dyskinesia, drawing, parkinson's disease, arm
0165-0270
47-52
Liu, X.
878efcac-76c6-4ca0-8f4a-425f1e9abdac
Carroll, C.B.
53eac18d-745e-450f-b425-a9c431d5fc4e
Wang, S.Y.
5c8eef3a-8029-47be-b82f-df420c5a7376
Zajicek, J.
d506a9c5-20ab-4930-b9f0-9aab103adcba
Bain, P.G.
6f63e03e-9273-426e-adc0-72eb1bec9e63
Liu, X.
878efcac-76c6-4ca0-8f4a-425f1e9abdac
Carroll, C.B.
53eac18d-745e-450f-b425-a9c431d5fc4e
Wang, S.Y.
5c8eef3a-8029-47be-b82f-df420c5a7376
Zajicek, J.
d506a9c5-20ab-4930-b9f0-9aab103adcba
Bain, P.G.
6f63e03e-9273-426e-adc0-72eb1bec9e63

Liu, X., Carroll, C.B., Wang, S.Y., Zajicek, J. and Bain, P.G. (2005) Quantifying drug-induced dyskinesias in the arms using two different spiral-drawing tasks. Journal of Neuroscience Methods, 144 (1), 47-52. (doi:10.1016/j.jneumeth.2004.10.005).

Record type: Article

Abstract

In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are designed to, respectively, represent the continuous and discrete arm motions, and the size of the spiral is decided so that both the distal and proximal arm joints are involved. Fifteen PD patients, average disease duration 14.4+/-7.4 years, were assessed 30 min after a levodopa challenge whilst performing circular and square spiral-drawing tasks. The velocity of drawing movements was computed and the amplitude of the involuntary dyskinetic movements was measured as the standard deviation of the drawing velocity (SD-DV). The mean amplitude of dyskinetic movements was compared between arms and tasks and was correlated with clinical measures including the Bain dyskinesia scale and the total unified Parkinson's disease rating scale (UPDRS) score. The results showed that there was no statistically significant difference in the amplitude of dyskinesias either between the arms or between the continuous (circular) and discrete (square) spiral drawings in this group of PD patients, but interestingly the interaction between arm and drawing pattern was significant. Significant correlations were found between the magnitude of dyskinesia measured from the spiral-drawing tasks and both the 'on' or 'off' UPDRS and also the Bain dyskinesia scale. We conclude that the drawing tasks may be used to provide an objective method of quantifying the severity of drug-induced dyskinesias in the arm in PD patients.

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More information

Published date: 15 May 2005
Keywords: dyskinesia, drawing, parkinson's disease, arm
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 49600
URI: http://eprints.soton.ac.uk/id/eprint/49600
ISSN: 0165-0270
PURE UUID: 6aa8d6c3-d91f-4553-8524-2a98592e864d

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Date deposited: 21 Nov 2007
Last modified: 15 Mar 2024 09:57

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Contributors

Author: X. Liu
Author: C.B. Carroll
Author: S.Y. Wang
Author: J. Zajicek
Author: P.G. Bain

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