The University of Southampton
University of Southampton Institutional Repository

Phantom limb pain relieved with different modalities of central nervous system stimulation: a clinical and functional imaging case report of two patients

Record type: Article

Phantom limb pain (PLP) is a type of neuropathic pain syndrome that has evoked much interest in scientific and clinical fields. The condition is often intractable and severely debilitating. Though there are anecdotal reports in the literature of successful management of individual cases with brain and spinal cord stimulation, it has not been possible to develop a system of management that is consistently successful, mainly due to the paucity of basic neurophysiological data about PLP and its pathways in the central nervous system (CNS). Functional imaging offers a way of collecting information about the basic mechanisms and pathways of PLP from patients without the excessive risk of more invasive penetrating electrode studies or the questionable reliability of animal data. There have been very few studies that have looked at the direct effect of CNS stimulation on regional brain activation and correlation with the pain state. We describe two cases of PLP that have been satisfactorily treated with CNS stimulation (motor cortex and then periventricular gray in one and spinal cord in the other) and have been subjected to single photon emission computed tomography (SPECT) studies when in pain and then during stimulation with recorded pain relief. We found that regardless of the site of stimulation in the CNS, pain relief is associated with blood flow changes in similar areas of the brain, mainly the parietal and cingulate cortex and also in the thalamic nuclei and the central gray matter. Further studies of this kind should reveal more about the complex mechanisms of PLP and other forms of neuropathic pain.

Full text not available from this repository.

Citation

Nandi, D., Yianni, J., Humphreys, J., Wang, S., O'Sullivan, V., Shepstone, B., Stein, J.F. and Aziz, T.Z. (2004) Phantom limb pain relieved with different modalities of central nervous system stimulation: a clinical and functional imaging case report of two patients Neuromodulation, 7, (3), pp. 176-183. (doi:10.1111/j.1094-7159.2004.04197.x).

More information

Published date: July 2004
Keywords: central nervous system phantom limb pain, SPECT, stimulation
Organisations: Human Sciences Group

Identifiers

Local EPrints ID: 49606
URI: http://eprints.soton.ac.uk/id/eprint/49606
ISSN: 1094-7159
PURE UUID: b95778a1-75f4-47ec-a1af-2016bbdcf1fb

Catalogue record

Date deposited: 22 Nov 2007
Last modified: 17 Jul 2017 14:55

Export record

Altmetrics

Contributors

Author: D. Nandi
Author: J. Yianni
Author: J. Humphreys
Author: S. Wang
Author: V. O'Sullivan
Author: B. Shepstone
Author: J.F. Stein
Author: T.Z. Aziz

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×