Defining treatment response in gambling disorder
Defining treatment response in gambling disorder
Background: gambling disorder is a common mental health condition, and a growing cause of concern globally. Despite the availability of well-validated self-report and clinical instruments to measure symptom severity, there has been no study to establish optimal thresholds for determining treatment response based on these measures.
Methods: data from 553 participants (aged 18-65 years) who had participated in previous pharmacological and psychotherapeutic clinical trials for gambling disorder were aggregated. Studies were included that collected Clinical Global Impression Improvement (CGI-I) at end-of-study (reference standard), as well as baseline and end-of-study symptom severity using the Gambling Symptom Assessment Scale (GSAS) and/or the Yale-Brown Obsessive-Compulsive Scale Modified for Pathological Gambling (PG-YBOCS). Receiver Operator Characteristic (ROC) analyses were conducted to identify optimal thresholds for determining treatment response.
Results: greater than 50% improvement in PG-YBOCS and
GSAS, PG-YBOCS, ROC, gambling, response, treatment, Response, Gambling, Treatment
382-386
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3
Ioannidis, Konstantinos
8ce68c02-51db-4249-966f-0b0af067bfff
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
9 November 2024
Grant, Jon E.
07372bd5-8a0d-42b4-b41b-e376c652acf3
Ioannidis, Konstantinos
8ce68c02-51db-4249-966f-0b0af067bfff
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Grant, Jon E., Ioannidis, Konstantinos and Chamberlain, Samuel R.
(2024)
Defining treatment response in gambling disorder.
Journal of Psychiatric Research, 180, .
(doi:10.1016/j.jpsychires.2024.11.006).
Abstract
Background: gambling disorder is a common mental health condition, and a growing cause of concern globally. Despite the availability of well-validated self-report and clinical instruments to measure symptom severity, there has been no study to establish optimal thresholds for determining treatment response based on these measures.
Methods: data from 553 participants (aged 18-65 years) who had participated in previous pharmacological and psychotherapeutic clinical trials for gambling disorder were aggregated. Studies were included that collected Clinical Global Impression Improvement (CGI-I) at end-of-study (reference standard), as well as baseline and end-of-study symptom severity using the Gambling Symptom Assessment Scale (GSAS) and/or the Yale-Brown Obsessive-Compulsive Scale Modified for Pathological Gambling (PG-YBOCS). Receiver Operator Characteristic (ROC) analyses were conducted to identify optimal thresholds for determining treatment response.
Results: greater than 50% improvement in PG-YBOCS and
Text
threshold_paper_gamblingdisorder-10-23-24
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Accepted/In Press date: 3 November 2024
e-pub ahead of print date: 4 November 2024
Published date: 9 November 2024
Keywords:
GSAS, PG-YBOCS, ROC, gambling, response, treatment, Response, Gambling, Treatment
Identifiers
Local EPrints ID: 496105
URI: http://eprints.soton.ac.uk/id/eprint/496105
ISSN: 0022-3956
PURE UUID: 90033982-9717-43ae-b363-bb494396cb8d
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Date deposited: 04 Dec 2024 17:35
Last modified: 19 Mar 2025 03:11
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Contributors
Author:
Jon E. Grant
Author:
Konstantinos Ioannidis
Author:
Samuel R. Chamberlain
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