Management of ganglioneuroma and ganglioneuroblastoma intermixed: a United Kingdom Childrens Cancer and Leukaemia Group (UK CCLG) nationwide study report
Management of ganglioneuroma and ganglioneuroblastoma intermixed: a United Kingdom Childrens Cancer and Leukaemia Group (UK CCLG) nationwide study report
Background: ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) represent benign variants of peripheral neuroblastic tumours. While historically surgical resection was recommended, watchful active observation has become the accepted management for a subset of patients.
Objectives: to review clinical features, biology, natural history and management of a retrospective UK CCLG study cohort of GN and GNBi, and compare outcomes of patients treated with surgical resection or watchful active observation.
Methods: retrospective review of histologically confirmed non-metastatic GN and GNBi diagnosed between 1990 and 2020.
Results: a total of 259 patients were identified (163 GN, 93 GNBi, median age 62 months). In all 201 (78%) had initial surgery and 58 (22%) were observed. Overall survival was 98%. Twenty-one of 58 observed (36%) required subsequent surgery due to progressive tumour growth (52%). Gross total resection (GTR) was achieved in 79% of patients with a 19% complication rate. GTR was obtained
ganglioneuroblastoma, ganglioneuroma, observation, surgery, surveillance
Burnand, Katherine M.
d868e621-6c12-499e-aa84-eee3f897f579
Neville, Jonathan
d6f42f0e-48a8-43ac-bb05-0f6692cf8a14
Budzanowski, Annita
81676b64-89d9-4d4e-8c36-9e1f96bac245
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf
Burnand, Katherine M.
d868e621-6c12-499e-aa84-eee3f897f579
Neville, Jonathan
d6f42f0e-48a8-43ac-bb05-0f6692cf8a14
Budzanowski, Annita
81676b64-89d9-4d4e-8c36-9e1f96bac245
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf
Burnand, Katherine M., Neville, Jonathan and Budzanowski, Annita
,
et al.
(2024)
Management of ganglioneuroma and ganglioneuroblastoma intermixed: a United Kingdom Childrens Cancer and Leukaemia Group (UK CCLG) nationwide study report.
Pediatric Blood and Cancer, 72 (2), [e31445].
(doi:10.1002/pbc.31445).
Abstract
Background: ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) represent benign variants of peripheral neuroblastic tumours. While historically surgical resection was recommended, watchful active observation has become the accepted management for a subset of patients.
Objectives: to review clinical features, biology, natural history and management of a retrospective UK CCLG study cohort of GN and GNBi, and compare outcomes of patients treated with surgical resection or watchful active observation.
Methods: retrospective review of histologically confirmed non-metastatic GN and GNBi diagnosed between 1990 and 2020.
Results: a total of 259 patients were identified (163 GN, 93 GNBi, median age 62 months). In all 201 (78%) had initial surgery and 58 (22%) were observed. Overall survival was 98%. Twenty-one of 58 observed (36%) required subsequent surgery due to progressive tumour growth (52%). Gross total resection (GTR) was achieved in 79% of patients with a 19% complication rate. GTR was obtained
Text
Ganglioneuroma paper PBC2024 manuscript final_with AbvTable
- Accepted Manuscript
Text
Pediatric Blood Cancer - 2024 - Burnand - Management of Ganglioneuroma and Ganglioneuroblastoma Intermixed A United
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Accepted/In Press date: 30 October 2024
e-pub ahead of print date: 24 November 2024
Keywords:
ganglioneuroblastoma, ganglioneuroma, observation, surgery, surveillance
Identifiers
Local EPrints ID: 496124
URI: http://eprints.soton.ac.uk/id/eprint/496124
ISSN: 1545-5017
PURE UUID: a6619289-6d0e-41b1-9fd3-923fef1ed763
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Date deposited: 04 Dec 2024 17:46
Last modified: 10 Jan 2025 02:48
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Author:
Katherine M. Burnand
Author:
Jonathan Neville
Author:
Annita Budzanowski
Corporate Author: et al.
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