Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems †

Lewis, Adam and Harris, Nicholas (2017) Modelling new techniques for improving separation in miniature capillary- and planar-based capillary electrophoresis systems †. Proceedings. (doi:10.3390/proceedings1040278).

Record type: Article

Abstract

The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications.

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