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Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modelling

Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modelling
Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modelling
We have investigated the complex formation/dissociation reaction between Ni2+ ions and the ligand pyridine-2-azo-p-dimethylaniline (PADA) in a glass micro-reactor operating under electrokinetic control. An in situ, microscope-imaging technique was used to determine the spatial and temporal evolution of the reaction within the channel network of the micro-reactor. Using appropriately controlled voltage sequences, a slug of PADA was injected into a stream of Ni2+ solution. Under the experimental reaction conditions used, Ni2+ ions are mixed with the PADA as a consequence of the species different electrokinetic mobilities allowing the complex formation to occur at the trailing edge of the PADA slug. Following complex formation, reversal of the flow results in the partial re-formation of free PADA by dissociation of the complex, demonstrating that voltage control can be used to drive the reaction either forwards or backwards. We discuss the methods whereby all the parameters required to predict the spatial and temporal evolution of the reaction in the micro-reactor can be either measured or estimated. Based on the estimated parameters, model calculations of the concentration profiles as a function of time show good agreement with the measured data
1473-0197
102-112
Fletcher, Paul D.I.
a34b4165-1e93-4661-bd28-71f1fa9b002b
Haswell, Stephen J.
443a65de-9f13-4fbf-8b70-7de24004957b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Fletcher, Paul D.I.
a34b4165-1e93-4661-bd28-71f1fa9b002b
Haswell, Stephen J.
443a65de-9f13-4fbf-8b70-7de24004957b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1

Fletcher, Paul D.I., Haswell, Stephen J. and Zhang, Xunli (2002) Electrokinetic control of a chemical reaction in a lab-on-a-chip micro-reactor: measurement and quantitative modelling. Lab on a Chip, 2, 102-112. (doi:10.1039/b201685k).

Record type: Article

Abstract

We have investigated the complex formation/dissociation reaction between Ni2+ ions and the ligand pyridine-2-azo-p-dimethylaniline (PADA) in a glass micro-reactor operating under electrokinetic control. An in situ, microscope-imaging technique was used to determine the spatial and temporal evolution of the reaction within the channel network of the micro-reactor. Using appropriately controlled voltage sequences, a slug of PADA was injected into a stream of Ni2+ solution. Under the experimental reaction conditions used, Ni2+ ions are mixed with the PADA as a consequence of the species different electrokinetic mobilities allowing the complex formation to occur at the trailing edge of the PADA slug. Following complex formation, reversal of the flow results in the partial re-formation of free PADA by dissociation of the complex, demonstrating that voltage control can be used to drive the reaction either forwards or backwards. We discuss the methods whereby all the parameters required to predict the spatial and temporal evolution of the reaction in the micro-reactor can be either measured or estimated. Based on the estimated parameters, model calculations of the concentration profiles as a function of time show good agreement with the measured data

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Published date: April 2002

Identifiers

Local EPrints ID: 49704
URI: http://eprints.soton.ac.uk/id/eprint/49704
ISSN: 1473-0197
PURE UUID: 9a294f3d-1a1b-4e7b-9219-0a35f46b885e
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571

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Date deposited: 23 Nov 2007
Last modified: 16 Mar 2024 03:55

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Contributors

Author: Paul D.I. Fletcher
Author: Stephen J. Haswell
Author: Xunli Zhang ORCID iD

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