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A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing

A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing
A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing
Microfabricated systems have recently become useful for routing particles to precise locations in microfluidic channels. In this paper we discuss the modeling, fabrication and characterization of such a platform that combines acoustic forces and ac dielectrophoresis (DEP). This system integrates a bulk lead zirconate titanate (PZT) slab with substrate patterned microelectrodes for DEP manipulation of particles. Moreover, a one-dimensional transmission line model is presented to understand the coupling of the acoustic and dielectrophoretic transducers with the microdevice. While the acoustic model does not predict the lateral coupling in the system, it does provide some insight into axial (thickness-mode) frequencies of operation. Experiments are also conducted in which particles were routed into a large (0.75 mm wide) microchannel and preconcentrated and focused into coarse bundles by coupling an acoustic wave into the channel. Subsequently, particles are further focused into single file particle streams using interdigitated DEP electrodes. This system can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.
acoustics, dielectrophoresis, microfluidics, particle focusing
0925-4005
645-652
Ravula, Surendra K.
8e032834-92ed-4984-9cdc-3369d097e8ab
Branch, Darren W.
af0f49d0-4ae9-4d5a-a375-d9c933806989
James, Conrad D.
d9b21df4-ea14-4035-a65d-c4380e86a591
Townsend, Rosemary J.
0452b21c-a758-4d4a-925b-1511d9296d62
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Kaduchak, Gregory
a5c06549-08f6-4b87-9306-29899cd6651c
Ward, Mike
b8c86155-1e1e-4d1d-b334-778a7fdd9e54
Brener, Igal
8b7f3803-54ae-4c8c-b066-7ff54e7ba841
Ravula, Surendra K.
8e032834-92ed-4984-9cdc-3369d097e8ab
Branch, Darren W.
af0f49d0-4ae9-4d5a-a375-d9c933806989
James, Conrad D.
d9b21df4-ea14-4035-a65d-c4380e86a591
Townsend, Rosemary J.
0452b21c-a758-4d4a-925b-1511d9296d62
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Kaduchak, Gregory
a5c06549-08f6-4b87-9306-29899cd6651c
Ward, Mike
b8c86155-1e1e-4d1d-b334-778a7fdd9e54
Brener, Igal
8b7f3803-54ae-4c8c-b066-7ff54e7ba841

Ravula, Surendra K., Branch, Darren W., James, Conrad D., Townsend, Rosemary J., Hill, Martyn, Kaduchak, Gregory, Ward, Mike and Brener, Igal (2008) A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing. Sensors and Actuators B: Chemical, 130 (2), 645-652. (doi:10.1016/j.snb.2007.10.024).

Record type: Article

Abstract

Microfabricated systems have recently become useful for routing particles to precise locations in microfluidic channels. In this paper we discuss the modeling, fabrication and characterization of such a platform that combines acoustic forces and ac dielectrophoresis (DEP). This system integrates a bulk lead zirconate titanate (PZT) slab with substrate patterned microelectrodes for DEP manipulation of particles. Moreover, a one-dimensional transmission line model is presented to understand the coupling of the acoustic and dielectrophoretic transducers with the microdevice. While the acoustic model does not predict the lateral coupling in the system, it does provide some insight into axial (thickness-mode) frequencies of operation. Experiments are also conducted in which particles were routed into a large (0.75 mm wide) microchannel and preconcentrated and focused into coarse bundles by coupling an acoustic wave into the channel. Subsequently, particles are further focused into single file particle streams using interdigitated DEP electrodes. This system can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

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More information

e-pub ahead of print date: 23 October 2007
Published date: 28 March 2008
Keywords: acoustics, dielectrophoresis, microfluidics, particle focusing
Organisations: Electro-Mechanical Engineering

Identifiers

Local EPrints ID: 49715
URI: http://eprints.soton.ac.uk/id/eprint/49715
ISSN: 0925-4005
PURE UUID: 67a88af1-1ccb-460d-8785-fe18781a7f9e
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 26 Nov 2007
Last modified: 16 Mar 2024 02:41

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Contributors

Author: Surendra K. Ravula
Author: Darren W. Branch
Author: Conrad D. James
Author: Rosemary J. Townsend
Author: Martyn Hill ORCID iD
Author: Gregory Kaduchak
Author: Mike Ward
Author: Igal Brener

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