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A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing

Record type: Article

Microfabricated systems have recently become useful for routing particles to precise locations in microfluidic channels. In this paper we discuss the modeling, fabrication and characterization of such a platform that combines acoustic forces and ac dielectrophoresis (DEP). This system integrates a bulk lead zirconate titanate (PZT) slab with substrate patterned microelectrodes for DEP manipulation of particles. Moreover, a one-dimensional transmission line model is presented to understand the coupling of the acoustic and dielectrophoretic transducers with the microdevice. While the acoustic model does not predict the lateral coupling in the system, it does provide some insight into axial (thickness-mode) frequencies of operation. Experiments are also conducted in which particles were routed into a large (0.75 mm wide) microchannel and preconcentrated and focused into coarse bundles by coupling an acoustic wave into the channel. Subsequently, particles are further focused into single file particle streams using interdigitated DEP electrodes. This system can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

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Citation

Ravula, Surendra K., Branch, Darren W., James, Conrad D., Townsend, Rosemary J., Hill, Martyn, Kaduchak, Gregory, Ward, Mike and Brener, Igal (2008) A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing Sensors and Actuators B: Chemical, 130, (2), pp. 645-652. (doi:10.1016/j.snb.2007.10.024).

More information

e-pub ahead of print date: 23 October 2007
Published date: 28 March 2008
Keywords: acoustics, dielectrophoresis, microfluidics, particle focusing
Organisations: Electro-Mechanical Engineering

Identifiers

Local EPrints ID: 49715
URI: http://eprints.soton.ac.uk/id/eprint/49715
ISSN: 0925-4005
PURE UUID: 67a88af1-1ccb-460d-8785-fe18781a7f9e
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 26 Nov 2007
Last modified: 17 Jul 2017 14:55

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Contributors

Author: Surendra K. Ravula
Author: Darren W. Branch
Author: Conrad D. James
Author: Rosemary J. Townsend
Author: Martyn Hill ORCID iD
Author: Gregory Kaduchak
Author: Mike Ward
Author: Igal Brener

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