Purinergic signaling in bone
Purinergic signaling in bone
Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells. Since then the expression of nearly all the P2Y and P2X receptors by osteoblasts and osteoclasts has been reported, mediating multiple processes including cell proliferation, differentiation, function, and death. This review will highlight the most recent developments in the field of purinergic signaling in bone, with a special emphasis on recent work resulting from the European Framework 7 funded collaboration ATPBone, as well as Arthritis Research UK and Bone Research Society supported projects.
ATP, bone, osteoblast, osteoclast, osteoporosis, P2x, P2y, purinergic signaling
Rumney, Robin M.H.
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Wang, Ning
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Agrawal, Ankita
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Gartland, Alison
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Rumney, Robin M.H.
fa3de9f8-b604-44e2-9e72-3e57980ce67f
Wang, Ning
65388ff2-b010-4407-ab51-3cd9717f7814
Agrawal, Ankita
16698cff-2a8f-43c1-9d1c-b48cd4ded471
Gartland, Alison
3cacfde2-abf7-45f7-b2fb-91102dfa86ab
Rumney, Robin M.H., Wang, Ning, Agrawal, Ankita and Gartland, Alison
(2012)
Purinergic signaling in bone.
Frontiers in Endocrinology, 3, [116].
(doi:10.3389/fendo.2012.00116).
Abstract
Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal functioning of bone cells. Since then the expression of nearly all the P2Y and P2X receptors by osteoblasts and osteoclasts has been reported, mediating multiple processes including cell proliferation, differentiation, function, and death. This review will highlight the most recent developments in the field of purinergic signaling in bone, with a special emphasis on recent work resulting from the European Framework 7 funded collaboration ATPBone, as well as Arthritis Research UK and Bone Research Society supported projects.
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fendo-03-00116
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Accepted/In Press date: 4 September 2012
e-pub ahead of print date: 19 September 2012
Keywords:
ATP, bone, osteoblast, osteoclast, osteoporosis, P2x, P2y, purinergic signaling
Identifiers
Local EPrints ID: 497308
URI: http://eprints.soton.ac.uk/id/eprint/497308
ISSN: 1664-2392
PURE UUID: 9807b969-ac44-4911-8ecb-7301df6e04fb
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Date deposited: 17 Jan 2025 18:04
Last modified: 18 Jan 2025 02:50
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Contributors
Author:
Robin M.H. Rumney
Author:
Ning Wang
Author:
Ankita Agrawal
Author:
Alison Gartland
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