Purinergic signalling in osteoblasts
Purinergic signalling in osteoblasts
The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to bone disease. The exact mechanisms balancing these actions are not fully known, although several regulatory systems are known to be involved. The involvement of purinergic signalling in bone has come to light over the past 20 years or so. This review will highlight the current knowledge of purinergic signalling in osteoblasts - covering expression of P2 receptors, mechanisms of ATP release and degradation, P2 receptor mediated signalling and finally the functional consequences of P2 receptor signalling in bone.
extracellular ATP, osteoblast, P2 receptors, P2X, P2Y, purinergic signaling
16-29
Gartland, Alison
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Orriss, Isabel R.
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Rumney, Robin M.H.
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Bond, Alistair P.
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Arnett, Timothy
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Gallagher, James A.
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1 January 2012
Gartland, Alison
3cacfde2-abf7-45f7-b2fb-91102dfa86ab
Orriss, Isabel R.
9071f515-7a7b-4cdc-abc3-6376177121c5
Rumney, Robin M.H.
fa3de9f8-b604-44e2-9e72-3e57980ce67f
Bond, Alistair P.
49644864-5cf8-44f6-9018-9999e04a25a8
Arnett, Timothy
b7802b3a-7c94-433e-a619-c89ac807d86f
Gallagher, James A.
59a9c42b-a826-4df7-9b2b-442c7b690116
Gartland, Alison, Orriss, Isabel R., Rumney, Robin M.H., Bond, Alistair P., Arnett, Timothy and Gallagher, James A.
(2012)
Purinergic signalling in osteoblasts.
Frontiers in Bioscience, 17 (1), .
(doi:10.2741/3912).
Abstract
The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to bone disease. The exact mechanisms balancing these actions are not fully known, although several regulatory systems are known to be involved. The involvement of purinergic signalling in bone has come to light over the past 20 years or so. This review will highlight the current knowledge of purinergic signalling in osteoblasts - covering expression of P2 receptors, mechanisms of ATP release and degradation, P2 receptor mediated signalling and finally the functional consequences of P2 receptor signalling in bone.
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Published date: 1 January 2012
Keywords:
extracellular ATP, osteoblast, P2 receptors, P2X, P2Y, purinergic signaling
Identifiers
Local EPrints ID: 497397
URI: http://eprints.soton.ac.uk/id/eprint/497397
ISSN: 1093-9946
PURE UUID: 57236b8f-3628-4531-946c-fc5eafbdba59
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Date deposited: 21 Jan 2025 18:10
Last modified: 22 Jan 2025 02:49
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Contributors
Author:
Alison Gartland
Author:
Isabel R. Orriss
Author:
Robin M.H. Rumney
Author:
Alistair P. Bond
Author:
Timothy Arnett
Author:
James A. Gallagher
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