A concise review on the role of selenium for bone cancer applications
A concise review on the role of selenium for bone cancer applications
Cancer is one of the most challenging health problems in the world. Several clinical treatments have beendeveloped, but all presenting several limitations. Among different types of cancer, bone cancer is less common,and limited new clinical treatment strategies have been proposed. Recently, a range of advanced materials hasbeen investigated and applied for bone cancer treatment applications. However, due to the unique physiologicalproperties of the bone tissue (a load-bearing tissue), the selection of the right type of material or the combinationof suitable functional materials and base materials are critical. Selenium has been reported to present specifictargeting inhibition effects on bone cancer without affecting the surrounding healthy tissue, revealing a hugepotential for the development of new bone cancer treatment strategies. This paper presents a concise review onthe use of selenium for bone cancer applications, discussing main synthesis methods, biocompatibility, andcytotoxicity aspects and the combination of selenium with a wide range of ceramics, metals, and polymers.Future perspectives and the novel concept of a dual-functional scaffold for both cancer treatment and new boneregeneration are also discussed.
Bone, Cancer, Selenium, Tissue engineering
Hou, Yanhao
082d81da-35ae-4632-8e53-94a6b3a2fe99
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
25 April 2021
Hou, Yanhao
082d81da-35ae-4632-8e53-94a6b3a2fe99
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
Hou, Yanhao, Wang, Weiguang and Da Silva Bartolo, Paulo Jorge
(2021)
A concise review on the role of selenium for bone cancer applications.
Bone, 149, [115974].
(doi:10.1016/j.bone.2021.115974).
Abstract
Cancer is one of the most challenging health problems in the world. Several clinical treatments have beendeveloped, but all presenting several limitations. Among different types of cancer, bone cancer is less common,and limited new clinical treatment strategies have been proposed. Recently, a range of advanced materials hasbeen investigated and applied for bone cancer treatment applications. However, due to the unique physiologicalproperties of the bone tissue (a load-bearing tissue), the selection of the right type of material or the combinationof suitable functional materials and base materials are critical. Selenium has been reported to present specifictargeting inhibition effects on bone cancer without affecting the surrounding healthy tissue, revealing a hugepotential for the development of new bone cancer treatment strategies. This paper presents a concise review onthe use of selenium for bone cancer applications, discussing main synthesis methods, biocompatibility, andcytotoxicity aspects and the combination of selenium with a wide range of ceramics, metals, and polymers.Future perspectives and the novel concept of a dual-functional scaffold for both cancer treatment and new boneregeneration are also discussed.
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A concise review on the role of selenium for bone cancer applications
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Accepted/In Press date: 19 April 2021
e-pub ahead of print date: 23 April 2021
Published date: 25 April 2021
Additional Information:
This research was supported by Rosetrees & Stoneygate Trust Enterprise Fellowship (Ref: A2750/M874 ) from Rosetrees Trust UK and Stoneygate Trust UK , and Engineering and Physical Sciences Research Council (EPSRC) UK, Global Challenges Research Fund (grant number EP/R015139/1 ). Publisher Copyright: © 2021 Elsevier Inc.
Keywords:
Bone, Cancer, Selenium, Tissue engineering
Identifiers
Local EPrints ID: 497767
URI: http://eprints.soton.ac.uk/id/eprint/497767
ISSN: 8756-3282
PURE UUID: eac66193-d0e8-45d0-9247-a6d78f3e7515
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Date deposited: 30 Jan 2025 17:59
Last modified: 22 Aug 2025 02:46
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Author:
Yanhao Hou
Author:
Weiguang Wang
Author:
Paulo Jorge Da Silva Bartolo
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