In vivo investigation of 3D printed polycaprolactone/graphene electro-active bone scaffolds
In vivo investigation of 3D printed polycaprolactone/graphene electro-active bone scaffolds
Additive manufactured scaffolds are widely used as 3D support structures for tissue engineering. This paper investigates the mechanisms behind bone regeneration due to the combined use of 3D printed poly(ɛ-caprolactone)/graphene (PCL/G) electro-active scaffolds and electrical stimulation. A comprehensive in vivo study was conducted to assess the proposed approach, using a rat model. Results show that the combined use of electro-active scaffolds and electrical stimulation therapy accelerates the bone regeneration process and the formation of more organised new bone, through fast angiogenesis, and a rapid transition to the mineralisation and bone remodelling phase. The mechanism is investigated and explained.
Lopes Nalesso, Paulo Roberto
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Wang, Weiguang
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Hou, Yanhao
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Bagne, Leonardo
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Pereira, Amanda Tavares
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Helaehil, Julia Venturini
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de Andrade, Thiago Antônio Moretti
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Chiarotto, Gabriela Bortolança
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Bartolo, Paulo
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Caetano, Guilherme Ferreira
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31 July 2021
Lopes Nalesso, Paulo Roberto
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Wang, Weiguang
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Hou, Yanhao
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Bagne, Leonardo
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Pereira, Amanda Tavares
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Helaehil, Julia Venturini
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de Andrade, Thiago Antônio Moretti
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Chiarotto, Gabriela Bortolança
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Bartolo, Paulo
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Caetano, Guilherme Ferreira
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Lopes Nalesso, Paulo Roberto, Wang, Weiguang, Hou, Yanhao, Bagne, Leonardo, Pereira, Amanda Tavares, Helaehil, Julia Venturini, de Andrade, Thiago Antônio Moretti, Chiarotto, Gabriela Bortolança, Bartolo, Paulo and Caetano, Guilherme Ferreira
(2021)
In vivo investigation of 3D printed polycaprolactone/graphene electro-active bone scaffolds.
Bioprinting, 24, [e00164].
(doi:10.1016/j.bprint.2021.e00164).
Abstract
Additive manufactured scaffolds are widely used as 3D support structures for tissue engineering. This paper investigates the mechanisms behind bone regeneration due to the combined use of 3D printed poly(ɛ-caprolactone)/graphene (PCL/G) electro-active scaffolds and electrical stimulation. A comprehensive in vivo study was conducted to assess the proposed approach, using a rat model. Results show that the combined use of electro-active scaffolds and electrical stimulation therapy accelerates the bone regeneration process and the formation of more organised new bone, through fast angiogenesis, and a rapid transition to the mineralisation and bone remodelling phase. The mechanism is investigated and explained.
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In vivo investigation of 3D printed polycaprolactonegraphene electro-active bone scaffolds
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Accepted/In Press date: 26 July 2021
e-pub ahead of print date: 29 July 2021
Published date: 31 July 2021
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Local EPrints ID: 497784
URI: http://eprints.soton.ac.uk/id/eprint/497784
ISSN: 2405-8866
PURE UUID: 20c9570d-2305-4bb6-9a93-c84bb67edc7b
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Date deposited: 31 Jan 2025 17:39
Last modified: 22 Aug 2025 02:46
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Contributors
Author:
Paulo Roberto Lopes Nalesso
Author:
Weiguang Wang
Author:
Yanhao Hou
Author:
Leonardo Bagne
Author:
Amanda Tavares Pereira
Author:
Julia Venturini Helaehil
Author:
Thiago Antônio Moretti de Andrade
Author:
Gabriela Bortolança Chiarotto
Author:
Paulo Bartolo
Author:
Guilherme Ferreira Caetano
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