Electrospun highly porous poly(L-lactic acid)-dopamine- SiO₂ fibrous membrane for bone regeneration

Lu, Zihan, Wang, Weiguang, Zhang, Jing, Da Silva Bartolo, Paulo Jorge, Gong, Hugh and Li, Jiashen (2020) Electrospun highly porous poly(L-lactic acid)-dopamine- SiO₂ fibrous membrane for bone regeneration. Materials Science and Engineering C, 117, [111359]. (doi:10.1016/j.msec.2020.111359).

Abstract

Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used forbone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coatingstrength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane withhigh surface area has high potential for periosteum in the field of bone regeneration applications.

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Contributors

Author: Weiguang Wang

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