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Investigating the effect of carbon nanomaterials reinforcing poly(ε-Caprolactone) printed scaffolds for bone repair applications

Investigating the effect of carbon nanomaterials reinforcing poly(ε-Caprolactone) printed scaffolds for bone repair applications
Investigating the effect of carbon nanomaterials reinforcing poly(ε-Caprolactone) printed scaffolds for bone repair applications
Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approach in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and G oxide at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, G oxide seems to show some cytotoxicity, particular at high contents.
Biomanufactoring, Graphene, Graphene oxide, Poly (ε-caprolactone), Scaffolds, Tissue engineering
2424-8002
61-69
Hou, Yanhao
082d81da-35ae-4632-8e53-94a6b3a2fe99
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
Hou, Yanhao
082d81da-35ae-4632-8e53-94a6b3a2fe99
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf

Hou, Yanhao, Wang, Weiguang and Da Silva Bartolo, Paulo Jorge (2020) Investigating the effect of carbon nanomaterials reinforcing poly(ε-Caprolactone) printed scaffolds for bone repair applications. International Journal of Bioprinting, 6 (2), 61-69. (doi:10.18063/ijb.v6i2.266).

Record type: Article

Abstract

Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approach in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and G oxide at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, G oxide seems to show some cytotoxicity, particular at high contents.

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Accepted/In Press date: 1 April 2020
Published date: 21 April 2020
Keywords: Biomanufactoring, Graphene, Graphene oxide, Poly (ε-caprolactone), Scaffolds, Tissue engineering

Identifiers

Local EPrints ID: 497814
URI: http://eprints.soton.ac.uk/id/eprint/497814
ISSN: 2424-8002
PURE UUID: 3ac37c69-49ed-4992-b654-0c4003fc7c8b
ORCID for Weiguang Wang: ORCID iD orcid.org/0000-0002-8959-329X

Catalogue record

Date deposited: 31 Jan 2025 18:09
Last modified: 22 Aug 2025 02:46

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Contributors

Author: Yanhao Hou
Author: Weiguang Wang ORCID iD
Author: Paulo Jorge Da Silva Bartolo

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