A plasma-assisted bioextrusion system for tissue engineering
A plasma-assisted bioextrusion system for tissue engineering
A challenge for tissue engineering is to produce synthetic scaffolds of adequate chemical, physical and biological cues effectively. This paper describes a plasma-assisted bio-extrusion system to produce functional-gradient scaffolds; it comprises pressure-assisted and screw-assisted extruders, and plasma jets. This paper also describes how the system conducts plasma surface modification during the polycaprolactone scaffold fabrication process. Water contact angle and in vitro biological tests confirm that the plasma modification alters the hydrophilicity properties of synthetic polymers and promotes proliferation of cells, leading to homogeneous cell colonization. The results suggest this system is promising for producing functional gradient scaffolds of biomaterials.
Additive manufacturing, Biomedical, Tissue engineering
229-232
Liu, Fengyuan
34504cf0-2b1a-4b0b-afe3-6e6e7f86a193
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Mirihanage, Wajira
fc929099-b7ea-4127-886e-07f4ddc05b42
Hinduja, Srichand
4458d7aa-31a5-4670-ba45-c81e68d80669
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
10 July 2018
Liu, Fengyuan
34504cf0-2b1a-4b0b-afe3-6e6e7f86a193
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Mirihanage, Wajira
fc929099-b7ea-4127-886e-07f4ddc05b42
Hinduja, Srichand
4458d7aa-31a5-4670-ba45-c81e68d80669
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
Liu, Fengyuan, Wang, Weiguang, Mirihanage, Wajira, Hinduja, Srichand and Da Silva Bartolo, Paulo Jorge
(2018)
A plasma-assisted bioextrusion system for tissue engineering.
CIRP Annals, 67 (1), .
(doi:10.1016/j.cirp.2018.04.077).
Abstract
A challenge for tissue engineering is to produce synthetic scaffolds of adequate chemical, physical and biological cues effectively. This paper describes a plasma-assisted bio-extrusion system to produce functional-gradient scaffolds; it comprises pressure-assisted and screw-assisted extruders, and plasma jets. This paper also describes how the system conducts plasma surface modification during the polycaprolactone scaffold fabrication process. Water contact angle and in vitro biological tests confirm that the plasma modification alters the hydrophilicity properties of synthetic polymers and promotes proliferation of cells, leading to homogeneous cell colonization. The results suggest this system is promising for producing functional gradient scaffolds of biomaterials.
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e-pub ahead of print date: 1 May 2018
Published date: 10 July 2018
Additional Information:
Publisher Copyright: © 2018
Keywords:
Additive manufacturing, Biomedical, Tissue engineering
Identifiers
Local EPrints ID: 497820
URI: http://eprints.soton.ac.uk/id/eprint/497820
ISSN: 0007-8506
PURE UUID: f9df465f-374c-4bd9-bde4-32aa76e4ca44
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Date deposited: 31 Jan 2025 18:21
Last modified: 01 Feb 2025 03:20
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Contributors
Author:
Fengyuan Liu
Author:
Weiguang Wang
Author:
Wajira Mirihanage
Author:
Srichand Hinduja
Author:
Paulo Jorge Da Silva Bartolo
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