Engineering the biological performance of hierarchical nanostructured poly(ε-carpolactone) scaffolds for bone tissue engineering
Engineering the biological performance of hierarchical nanostructured poly(ε-carpolactone) scaffolds for bone tissue engineering
Scaffolds play an important role as physical substrates for cell proliferation and differentiation, leading to tissue regeneration. For bone applications, researchers are focusing on cellular or acellular biocompatible biodegradable polymeric scaffolds. However, high biological performance scaffolds are still required to meet actual clinical demands. This paper discusses a novel strategy to engineer the biological performance of polymeric scaffolds through the combined use of additive manufacturing, acetone vapour annealing surface treatment and dopamine grafting, enabling the fabrication of hierarchical nanostructured tissue engineering structures. Produced scaffolds present improved biological behaviour compared to conventional additive manufactured scaffolds, and similar mechanical properties, showing high potential for clinical applications.
Additive Manufacturing, Biomedical, Tissue Engineering
217-22
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Lu, Zihan
3c683377-930a-4f26-b6a8-e435b4bfa7ce
Li, Jiashen
68a211ee-56d5-4c0d-9c8b-c51235a1ca77
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
13 July 2020
Wang, Weiguang
0cc699c0-e7b3-49d0-8c84-1e9d63f747d8
Lu, Zihan
3c683377-930a-4f26-b6a8-e435b4bfa7ce
Li, Jiashen
68a211ee-56d5-4c0d-9c8b-c51235a1ca77
Da Silva Bartolo, Paulo Jorge
2c085472-871d-4ac1-8767-23e5fe9703cf
Wang, Weiguang, Lu, Zihan, Li, Jiashen and Da Silva Bartolo, Paulo Jorge
(2020)
Engineering the biological performance of hierarchical nanostructured poly(ε-carpolactone) scaffolds for bone tissue engineering.
CIRP Annals, 69 (1), .
(doi:10.1016/j.cirp.2020.04.044).
Abstract
Scaffolds play an important role as physical substrates for cell proliferation and differentiation, leading to tissue regeneration. For bone applications, researchers are focusing on cellular or acellular biocompatible biodegradable polymeric scaffolds. However, high biological performance scaffolds are still required to meet actual clinical demands. This paper discusses a novel strategy to engineer the biological performance of polymeric scaffolds through the combined use of additive manufacturing, acetone vapour annealing surface treatment and dopamine grafting, enabling the fabrication of hierarchical nanostructured tissue engineering structures. Produced scaffolds present improved biological behaviour compared to conventional additive manufactured scaffolds, and similar mechanical properties, showing high potential for clinical applications.
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e-pub ahead of print date: 17 May 2020
Published date: 13 July 2020
Keywords:
Additive Manufacturing, Biomedical, Tissue Engineering
Identifiers
Local EPrints ID: 497831
URI: http://eprints.soton.ac.uk/id/eprint/497831
ISSN: 0007-8506
PURE UUID: f1025c9e-d1be-4ec9-b163-306f85660b21
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Date deposited: 03 Feb 2025 17:34
Last modified: 04 Feb 2025 03:14
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Contributors
Author:
Weiguang Wang
Author:
Zihan Lu
Author:
Jiashen Li
Author:
Paulo Jorge Da Silva Bartolo
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